頁籤選單縮合
題名 | Oxidative Stress in Kawasaki Disease Patients with Coronary Artery Lesions=氧化壓力對有冠狀動脈病灶川崎氏症病童的影響 |
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作者 | 吳晃維; 潘仕晉; 劉道遠; 簡任宏; 翁根本; 葛魯蘋; Wu, Huang-wei; Pen, Shih-jin; Liu, Tao-yuan; Chien, Jen-hung; Weng, Ken-pen; Ger, Luo-ping; |
期刊 | Medical Journal of South Taiwan |
出版日期 | 20150600 |
卷期 | 11:1 2015.06[民104.06] |
頁次 | 頁1-8 |
分類號 | 417.515 |
語文 | eng |
關鍵詞 | 總抗氧化力; 冠狀動脈病灶; 川崎氏症; 氧化壓力; Total antioxidant power; Coronary artery lesions; Kawasaki disease; Oxidative stress; |
中文摘要 | 目的:氧化壓力於川崎氏症的發病過程中扮演重要角色,有關這方面文獻有限,本研究要評估氧化壓力和川崎氏症冠狀動脈病灶相關性。方法:共有18位川崎氏症病童(1.73±1.69歲,男/女10/8)和10位健康對照者(1.80±1.51歲,男/女6/4),川崎氏症病童進一步分為急性期有冠狀動脈病灶(n=9)和無冠狀動脈病灶(n=9)兩小組,所有研究者接受抽血檢測總抗氧化力。結果:川崎氏症病童的總抗氧化力由免疫球蛋白治療前至亞急性期明顯上升,並於恢復期,明顯下降;有冠狀動脈病灶川崎氏症病童的總抗氧化力,由免疫球蛋白治療前至亞急性期逐步明顯上升,並於恢復期明顯下降;無冠狀動脈病灶川崎氏症病童的總抗氧化力,免疫球蛋白治療前後無明顯變化,至亞急性期才明顯上升;各期和健康對照者的總抗氧化力相較,沒有統計上差異性;亞急性期,無冠狀動脈病灶川崎氏症病童的總抗氧化力,比有冠狀動脈病灶川崎氏症病童明顯較低。結論:本研究顯示有冠狀動脈病灶川崎氏症病童的高總抗氧化力期間較長,可能反映較嚴重氧化壓力。 |
英文摘要 | Objective: Oxidative stress may play an important role in the pathogenesis of Kawasaki disease (KD). The literature regarding the involvement of oxidative stress in KD is limited. This study aimed to investigate the relationship of oxidative stress and coronary artery lesions (CALs) in KD. Methods: The study enrolled 18 KD patients (1.73±1.69 yrs, M/F 10/8) and 10 normal controls (1.80±1.5l yrs, M/F 6/4). The KD patients were further classified into those with CALS (n=9) and without CALs (n=9) in acute stage. All KD patients had no CALs in chronic stage. Total antioxidant power was measured. Results: In KD patients, total antioxidant power (TAP) levels increased significantly from pre-IVIG to subacute phase (pre-IVIG vs subacute, p<O.OO 1), and declined significantly in convalescent phase (subacute vs convalescent, p=0.009). In KD patients with CALs, TAP levels after IVIG treatment (pre-IVIG vs post-IVIG, p=0.015) increased significantly from pre-IVIG to subacute phase (pre-IVIG vs subacute, p=0.008), and declined significantly in convalescent phase (subaucte vs convalescent, p=0.008). In KD patients without CALs, TAP levels after IVIG treatment (pre-IVIG vs post-IVIG, p=0.327) did not increase significantly until subacute phase (post-IVIG vs subaucte, p=0.086), but there was a significant difference of TAP levels between pre-IVIG and subacute phases (pre-IVIG vs subacute, p=0.008). In KD patients without CALs, TAP levels in convalescent phase were not significantly lower than those in subacute phase (subacute vs convalescent, p=0.5l5), but still significantly higher than those in preIVIG phase (pre-IVIG vs convalescent, p=0.008). Various phases of TAP levels in KD patients without CALs were not significantly higher than those in normal controls. Subacute-phase TAP in KD patients without CALs were significantly lower than those in KD patients with CALs. Conclusions: Our findings suggest the longer duration of high TAP in KD patients with CALs may reflect the more obvious oxidative stress. |
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