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題 名 | An Open Study to Compare the Efficacy and Tolerability of Terbinafine with Griseofulvin in Onychomycosis=Terbinafine 及 Griseofulvin在治療灰指甲療效及忍受性之比較研究 |
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作 者 | 曾興隆; 楊麗珍; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 15:3 1997.09[民86.09] |
頁 次 | 頁157-161 |
分類號 | 415.776 |
關鍵詞 | 灰指甲; 療效; 忍受性; Terbinafine; Griseofulvin; Onychomycosis; |
語 文 | 英文(English) |
中文摘要 | Griseofulvin has been regarded as a standard treatment of dermatophyte onychomycosis.�糞he treatment of onychomycosis with griseofulvin are unsatisfactory due to low cure rate; in most infections, therapy must be prolon- ged with accompanying problems of patient compliance and treatment failure.�� Onychomycosis caused by candida and mold are not respond to griseofulvin treat- ment.Ketoconazole is effective in the treatment of candida onychomycosis but this agent may cause hepatic damage in idiosyncratic patients. Recently, the clinical efficacy of oral terbinafine has been demonstrated in onychomycosis, tinea corporis and cutaneous candidiais.�鬆revious investigators showed that cures of onychomycosis required shorter course of treatment than with existing durgs.�� Totally 40 patients completed this study.20 in each group.The treatment course of terbinafine was 6 weeks(finger nails) or 4 months (toe nails), wherease, of griseofulvin, around 6 and 8 months.Every patient received KOH examination, fungal culture and/or histopathological examination before and after treatment.Monitering of CBC, liver enzymes and urinalysis were performed before and every two weeks afer initiation.Result:85% of the terbinafine treated group obtained clinical and mycologic cure, whereas the griseofulvin treated group was 60% (p<0.05) Tolerability:In terbinafine treated group, diarrhea occurred in 2 patients and liver enzyme elevation in one,whereas in griseofulvin treated group, headache occurred in one, skin rash in one and liver enzyme elev- ation in two patients. Conclusion:The treatment of onychomycosis with terbinafine was well tolerated and achieved a short course-high cure rate,even in some candidal onychomycosis. |
英文摘要 | 灰指甲為慢性難治療的徽菌感染症。多年來皆以grisefulvin治療�薄C Griseofulvin之治療常不成功,因治療需長期,約6個月至18個月,病人常因失去耐心而中斷 治療�插C且griseofulvin只對dermatophyte引起之感染有效,對candida及其他mold引起之 感染無效。爾後ketoconazole上市,ketoconazole對candida引起之灰指甲有效,但對某些 人會引起嚴重的肝臟損害。最近,terbinafine被發現對dermatophyte引起之灰指甲有效, 且terbinafine亦可治療皮表之candida感染�獺A進一步發現,使用terbinafine治療灰指甲 ,療程較griseofulvin短很多。手指甲只需六週,腳趾甲需三個月,而且復發率較低�間C 本研究完成40個成人灰指甲之治療,每組各20人,terbinafine組只投藥六週(手指甲 )或四個月(腳趾甲);而griseofulvin則投與六至八個月。每個病人在治療前後都做KOH 檢查、徽菌培養及(或)病理組織檢查,每兩週檢查CBC、生化及小便。結果:85%使用 terbinafine治療病例可得臨床治療及徽菌檢查陰性,griseofulvin可得60%改善。忍受性方 面:三個terbinafine治療病人出現不良反應,兩例出現腹瀉,一例肝功能呈現異常。四個 griseofulvin治療病人出現不良反應,兩例肝功能異常,一例頭痛及另一例皮膚過敏。 結論灰指甲使用terbinafine治療,療程較短,且對candida有效,病人的忍受性良好, 沒有嚴重的不良反應。 |
本系統中英文摘要資訊取自各篇刊載內容。