查詢結果分析
來源資料
相關文獻
- Investigations of Breast Masses with Technetium-99m Labeled Anti-mucin Antibody and Technetium-99m-MIBI
- The Anti-Inflammatory Effect of a Long-Acting Theophylline (Unidur) in Patients with Bronchial Asthma
- 乳腺癌治驗
- 豬生殖與呼吸綜合症病毒「gp5重組蛋白」的表現與單株抗體之製備
- Utilization of Monoclonal and Polyclonal Antibodies to Monitor the Protecting and Challenging Strains of Zucchini Yellow Mosaic Virus in Cross Protection
- 99mTc標記抗粘蛋白McAb乳腺癌放射免疫顯像初步臨床研究
- 單株抗體製備
- ELISA, Western Blotting, Immunocytolocalization and Immunoaffinity Column for Naturally Occuring Bioactive Compounds Using Monoclonal Antibodies
- 牛乳蛋白單株抗體之製備
- Trastuzumab(Herceptin[feb9])--第一個用於治療癌症的單株抗體
頁籤選單縮合
| 題 名 | Investigations of Breast Masses with Technetium-99m Labeled Anti-mucin Antibody and Technetium-99m-MIBI=[fee6]Tc標幟抗粘蛋白單株抗體和MIBI乳腺腫瘤影像研究 |
|---|---|
| 作 者 | 吳錦昌; 吳浩榮; 劉增禮; 唐軍; | 書刊名 | 核子醫學雜誌 |
| 卷 期 | 12:3 1999.09[民88.09] |
| 頁 次 | 頁131-136 |
| 分類號 | 416.226 |
| 關鍵詞 | 乳腺癌; 乳腺閃爍影像; 單株抗體; Breast neoplasm; Scintimammography; Monoclonal antibodies; MIBI; |
| 語 文 | 英文(English) |
| 中文摘要 | 方法:為評估99mTc標幟抗乳腺癌粘蛋白單株抗體(McAb)放射免疫影像(RH),及比較99m Tc-McAb與99m Tc-MIBI乳腺影像詮斷乳腺癌及腋淋巴結轉移的臨床價值,本研完對17例乳腺瘤患者進行RII,其中9例間隔2-3天同時進行99m Tc-MIBI影像比較研究。 結果:9例原發展性乳腺癌中,8例為RII陽性,靈敏度88.9%;5例原發性乳腺癌伴隨腋淋巴結轉移病例中的4例,及1例右乳腺浸潤性導管癌根治術5年後出現右腋淋巴結轉移病例,RII發現淋巴結轉移;相反的,6例乳腺良性病變和1例右乳腺單純癌根治術7年後定期隨訪病人,RII為陰性。9例比較研完結果:5例原發性乳腺癌及其中的的2例伴腋淋巴結轉移病例,99m Tc-McAb RII和99m Tc-MIBI兩種影像均為陽性,但1例乳腺導管癌病例的同側1枚腋淋巴結反應增生,99m Tc-MIBI影像卻呈假陽性;其餘4例乳腺良性病例,RII陰性,其中1例99m Tc-MIBI 5分鐘時相影像圖呈假陽性。 結論:99m Tc標幟抗粘蛋白McAb和99m Tc-MIBI兩種影像均能靈敏地診斷乳腺癌及其淋巴結轉移,而99m Tc標幟抗粘蛋白McAb RIl特異性更強。 |
| 英文摘要 | Background: The aim of this study was to evaluate the efficacy of radioimmunoimaging (RII) with 99mTc-anti-mucin McAb in detecting breast cancer and to compare the accuracy of 99m Tc-McAb and 99m Tc-MIBI in detecting primary breast cancer and lymph node metastases. Methods: Seventeen patients with suspected breast lesions with/without axilla lymph node metastases were included in this study. All patients received intravenous injection of 740-925 MBq of 99m Tc-McAb. Nine of 17 patients received 740 MBq of 99m Tc-MIBI injection at the interval of 2 - 3 days after McAb injection for the comparison study of McAb and MIBI. At 2, 4, 5 and 24 hrs postinjection of McAb, or at 5 rain and 1.5 - 2 hrs postinjection of MIBI, planar lateral and anterior views with 1000 k to 2000 k counts were obtained. SPECT was performed in some of the studied cases. Results: RII showed positive images in 8 of 9 primary cancer patients, with sensitivity of 88.9%. In the malignant group, 6 of the 11 had axillary lymph node metastases. Localization of McAb in the axillary node metastases was observed in 5 of them. The sensitivity was 83.33%. Six patients with benign breast lesions and 1 patient with post-operative breast cancer without recurrence showed negative findings (TN) on McAb scan. For the comparison study of 9 patients, all of 5 known primary breast lesions and 2 axilla node metastases in these 5 patients were seen by both imaging procedures. MIBI gave false positive image of one reactive proliferation lesion in a patient with ductal cancer. Four benign lesions on McAb and 3 of these 4 Pesions on MIBI images were negative. One false positive lesion was seen on 5 min MIBI image. Conclusion: Both McAb and MIBI were sensitive in breast cancer imaging. McAb was more specific in detecting primary breast cancer and lymph node metastases. |
本系統中英文摘要資訊取自各篇刊載內容。