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相關文獻
- Invasive Pneumococcal Infections in Southern Taiwan: Incidence, Predisposing Factors, and Prognosis
- 兒童肺炎鏈球菌感染
- 醫師處方評估及病患用藥指導--肺炎鏈球菌腦膜炎病例及用藥討論
- Pneumonia Caused by Penicillin-Nonsusceptible Streptococcus Pneumoniae: Clinical Characteristics, Prognostic Factors, and Outcomes
- Antimicrobial Resistance and Serotype Distribution of Streptococcus Pneumoniae Strains in Central Taiwan
- 青黴素抗藥性肺炎鏈球菌感染之治療和預防
- Invasive Streptococcus Pneumoniae Infection Associated with Rapidly Fatal Outcome in Taiwan
- 認識肺炎鏈球菌
- Antibiotic Susceptibility of Streptococcus Pneumoniae
- 臺灣地區成年人細菌性腦膜炎
頁籤選單縮合
題名 | Invasive Pneumococcal Infections in Southern Taiwan: Incidence, Predisposing Factors, and Prognosis=南臺灣侵入性肺炎鏈球菌感染之發病率、誘發因子及預後 |
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作者姓名(中文) | 賴孟德; 賴永發; 王瑞隆; | 書刊名 | 胸腔醫學 |
卷期 | 14:3 1999.09[民88.09] |
頁次 | 頁133-140 |
分類號 | 415.463 |
關鍵詞 | 肺炎鏈球菌; 侵入性肺炎鏈球菌感染; 盤尼西林抗藥性; Streptococcus pneumoniae; Invasive pneumococcal infection; Penicillin resistance; |
語文 | 英文(English) |
中文摘要 | 肺炎鏈球菌(Streptococcus pneumoniae)感染常見於老人、小孩及伴有潛 在性疾病的病人,尤其侵入性肺炎鏈球菌感染更為其主要死亡原因之一。在以 前,肺炎鏈球菌對於盤尼西林(Penicillin)幾乎無抗藥性,但最近幾年對盤尼西林 有抗藥性的肺炎鏈球菌比例逐年升高,幾乎皆高於50 %。在世界上比例較高的 地區如南非、南美、西班牙、東歐、日本及韓國等。為了解侵入性肺炎鏈球菌感 染在台灣的發病率及死亡率,我們分析了1997年高雄長庚醫院整年的住院病 人,其中有93位從各種檢體中培養出肺炎鏈球菌。當中屬於侵入性肺炎鏈球菌 感染者共有54位,故發病率為每十萬人中有84人,而其中菌血症患者佔91%。 肺炎鏈球菌對盤尼西林有抗藥性者為41%,比去年37%為高,而死亡率為27%。 但若針對侵入性肺炎鏈球菌感染者之死亡率則更高為35%。侵入性肺炎鏈球菌感 染者常併有之潛在性疾病有肝臟疾病、腎臟疾病及糖尿病,其中以和肝臟有相關 者最高共佔41%。另外值得注意的是伴有腎臟疾病者之死亡率高達75%,比患 有肝臟疾病(50%)及糖尿病者(47%)為高。據國外研究顯示65歲以上之老人或伴 有潛在性疾病的病人對肺炎鏈球菌疫苗皆有良好之抗體反應,且可維持4-5年。 所以在台灣對於肺炎鏈球菌感染之高危險群,為了降低發病率及死亡率實有考慮 接種肺炎鏈球菌疫苗的必要性。 |
英文摘要 | The worldwide incidence of penicillin-resistant Streptococcus pneumoniae has increased dramatically in recent years and currently up to 50% of pneumococci are reportedly resistant to penicillin in some countries. We retrospectively analyzed the records of patients with pneumococcal infection admitted to Chang Gung Memorial Hospital, Kaohsiung, from January 1, 1997 to December 31, 1997. S. pneumoniae had been isolated from 93 of 65706 admitted patients during the study period, 59 (63%) males and 34 (37%) females. The patient's age ranged from 1 month to 89 years (mean: 45.9±25.9 years); 24 (26%) were £ 17 years old, 33(35%) were 18-64 years old, and 36 (39%) were 3 65 years old. Of the 93 patients, 54 (58%) had documented invasive pneumococcal infection isolated from normally sterile fluids such as blood, CSF, pleural fluid, and amniotic fluid. The types of invasive pneumococcal infections included pneumonia (40), urinary tract infection (3), meningitis (2), peritonitis (3), liver abscess (2), biliary tract infection (1) and uterine infection (1). The incidence of invasive pneumococcal infection was 84 cases per 100,000 over the study period, 91% of which was pneumococcal bacteremia. The penicillin-resistance rate of S. pneumoniae at our hospital in 1997 was 41%, higher than the 37% reported in 1996. The mortality rate for invasive pneumococcal infection was 35% (19/54). Common underlying diseases associated with pneumococcal infection were liver diseases, renal diseases, and diabetes mellitus (DM). The most common was liver disease (41%), but the underlying disease with the highest mortality rate was renal disease (75%), higher than that of liver disease (50%) and DM (47%). The use of pneumococcal vaccine is suggested for high risk populations who are likely to acquire severe pneumococcal infections in Taiwan. |
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