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| 題 名 | Management of Ogilvie's Syndrome with Neostigmine: A Simple, Safe and Effective Method=以Neostigmine來治療急性大腸假性阻塞症:一種簡單、安全又有效的治療方法 |
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| 作 者 | 糠榮誠; 饒樹文; 趙培傑; 吳昌杰; | 書刊名 | 中華民國外科醫學會雜誌 |
| 卷 期 | 32:3 民88.05-06 |
| 頁 次 | 頁120-124 |
| 分類號 | 416.245 |
| 關鍵詞 | 急性大腸假性阻塞症; Neostigmine; Ogilvie's syndrome; Acute colonic pseudo-obstruction; |
| 語 文 | 英文(English) |
| 中文摘要 | 我們的目的是要介紹一種附交感神經亢進藥物:Neostigmine,使用於急性大腸假性阻塞症(Ogilvie's Syndrome)的病人。在最近一年共有五位病人診斷為急性大腸假性阻塞症,男女比例為三比二,平均年齡為67.6歲。五位都接受大腸直腸鏡檢查及減壓治療;症狀未明顯改善後,繼續接受Neostigmine點滴注射治療,同時在心電圓的監測下。五位病人在注射Neostigmine後約5至30分鐘即排氣或排便;只有一位因復發而第二天再接受第二次注射Neostigmine,臨床症狀明顯改善,沒有人須要接受手術治療,同時在住院期間也沒有人再復發。所以我們認為以Neostigmine使用於急性大腸假性阻塞症(Ogilvie's Syndrome)的病人,是一種既有效又安全的治療方法。 |
| 英文摘要 | To introduce a simple, safe and effective method in the management of Ogilvie's syndrome (acute colonic pseudo-obstruction) with intravenous neostigmine, a prospective study was undertaken with five consecutive patients (mean age 67.6 [ range 56 to 84 ] years) who had barium enema-confirmed Ogilvie's syndrome. After conservative treatment and colonoscopic decompression, the five patients had partial resolution of abdominal distention and were given intravenous neostigmine (2.5 mg in 100 ml normal saline for 60 minutes) while monitored by EKG. Rapid and dramatic decompression of large bowel distention occurred in all five patients after infusion with intravenous neostigmine for 5 to 30 minutes. One patient experienced a recurrence and received a second dose of the drug the next day. No patient required surgical decompression of the large bowel. Intravenous neostigmine was a simple and effective treatment for Ogilvie's syndrome with a lower morbidity and mortality rate than colonoscopic and surgical decompression of the large bowel. Additionally, the result supported the theory of the existence of excessive parasympathetic suppression in Ogilvie's syndrome. |
本系統中英文摘要資訊取自各篇刊載內容。