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頁籤選單縮合
題 名 | Subthalamic Surgery for Advanced Parkinson's Disease |
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作 者 | Su,Philip C.; | 書刊名 | Acta Neurologica Taiwanica |
卷 期 | 8:2 1999.06[民88.06] |
頁 次 | 頁83-90 |
分類號 | 415.83 |
關鍵詞 | 帕金森氏症; Parkinson's disease; |
語 文 | 英文(English) |
英文摘要 | Multiplex polymerase chain reaction (PCR) is widely used to detect exon deletions of the dystrophin gene in patients with Duchenne and Becker muscular dystrophy (DMD/BMD). Using 20 pairs of primers for triplex PCR amplifications, we found 55% (11/20) of our DMD/BMD patients had intragenic deletions. However when the reliability of triplex PCR was further onfirmed by independent PCR assays using single pairs of primers, only 30% (6/20) of the patients were found to have deletions within the 20 exons. This is the lowest percentage reported to date. Overestimation of the exon deletions by this multiplex PCR assay might be a consequence of the quality of template DNA or the microenvironment of the analyzed loci. The low number of patients studied or ethnic variation may have contributed to the low deletion rate in our study. |
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