頁籤選單縮合
題名 | Effects of Protective Colloids upon Properties of Ethylcellulose Microcapsules Prepared from Various Non-Solvent Addition Methods=保護性膠體對各種非溶濟添加法製備乙基纖維素微膠粒之影響 |
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作者 | 邱信程; 駱俊良; 王富亞; 許哲; Chiu, Hsin-cheng; Lo, Chun-liang; Wang, Fu-ya; Hsu, Jer; |
期刊 | Journal of the Chinese Institute of Chemical Engineers |
出版日期 | 19991100 |
卷期 | 30:6 1999.11[民88.11] |
頁次 | 頁491-499 |
分類號 | 418.632 |
語文 | eng |
關鍵詞 | 保護性膠體; 非溶濟添加法; 乙基纖維素微膠粒; Microencapsulation; Protective colloids; Ethylcellulose; Theophylline; |
中文摘要 | 在本研究中,我們利用各種非溶劑添加法製備含有茶鹼的乙基纖維素微膠粒。並 探討添加保護性膠體對微膠粒的性質影響。實驗結果顯示添加適量的保護性膠體可減少微膠 粒聚集情形,並使得微膠粒之表面較為緊密與平順。於保護性膠體的存在下,利用乳化非溶 劑添加法可製備單核 (mononucleated) 的乙基纖維素微膠粒。 因微膠粒的聚集現象,茶鹼 的釋放行為乃遵循基質中擴散控制模式,其釋放速率的快慢則依微膠粒的聚集程度與孔隙度 而定。 |
英文摘要 | Preparation of ethylcellulose microcapsules containing theophylline was performed by simple non-solvent addition and emulsion non-solvent addition methods in the presence of polybutadiene or polyisobutylene as a protective colloid. The effects of the protective colloids upon the properties of microcapsules with respect to the size distribution, drug content, ethylcellulose loss and porosity were characterized. The results indicate that, in the presence of an appropriate amount of the protective colloid, the extent of aggregation was reduced and the surface became smoother and less porous. Mononucleated microcapsules were obtained by the emulsion non-solvent addition method in the presence of polyisobutylene. Owing to the occurrence of aggregation, the theophylline release from microcapsules appeared to follow the diffusion-controlled matrix model, the release rate being dependent upon the extent of aggreation and the porosity of microcapsules. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。