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| 題 名 | 乙基纖維素--menadiol微膠粒之製備與保護性膠體之影響=Preparation of Ethylcellulos-e-Menadiol Microcapsules and Investigation of Their Properties in the Presence of a Protective Colloid |
|---|---|
| 作 者 | 王富亞; 邱信程; | 書刊名 | 興大工程學刊 |
| 卷 期 | 11:2 2000.06[民89.06] |
| 頁 次 | 頁23-34 |
| 分類號 | 418.4 |
| 關鍵詞 | 微包覆; 保護性膠體; 乙基纖維素; Microencapsulation; Protective colloid; Menadiol; Ethylcellulose; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 本研究中,我們利用非溶劑添加乳化法製備含有menadiol之乙基纖維素微膠粒,並 探討添加保護性膠體polyisobutylene對於乙基纖維素微膠粒性質的影響。結果含menadiol的乙 基纖維素微膠粒性質顯示出添加適量的保護性膠體可以減少微膠粒聚集情形,並使得微膠 粒表面更為緊密與平滑。在保護性膠體的存在下,凝膠過程易產生空心且穩定的小凝膠液 滴,造成乙基纖維素流失量增加。適度添加保護性膠體造成微膠粒的表面平滑及減少孔隙 度皆造成藥物釋放延遲的現象。保護性膠體的微量添加雖可減少微膠粒結塊情形,但因形 成小孔隙的密度增加,反而提高其平均孔隙度。當保護性膠體添加過量時,則造成溶液黏 度過高及凝膠液滴的膨脹,導致膠狀物的形成並造成大粒徑微膠粒的產生。核質藥物 menadiol是屬於氧化危害機制類的新穎抗癌藥物,利用微包覆將menadiol經由口服之投藥路 徑傳遞至胃腸管道則是一種新的嘗試。 |
| 英文摘要 | In this study, ethylcellulose microcapsules containing menadiol were prepared by emulsion non-solvent addition method in the presence of polyisobutylene as a protective colloid. The effects of polyisobutylene upon the properties of microcapsules with respect to the drug contents, ethylcellulose loss and surface morphology were characterized. The results indicate that, in the presence of appropriate amounts of poly isobutylene, the aggregation of microcapsules was reduced and the surface became smoother than those prepared in the void of the protective colloid. However, higher amounts of small, stable, but empty coacervate droplets occurred in the presence of the protective colloid, leading to a more significant loss of ethylcellulose. By addition of the protective colloid, the release rate of menadiol from microcapsules was reduced with the reduction in specific surface area and porosity of microcapsules. In the presence of a small amount of polyisobutylene, porosity of microcapsules was enhanced due to the formation of fine pores at the surface of particles, although the extent of aggregation was concomitantly reduced. On the other hand, the aggregation occurred to a more significant extent at a high concentration of polyisobutylene owing to the increased viscosity of solution and breakage of coacervates into gel-like aggregates. In this study, menadiol, as a potential anticancer agent, was tested for the first time as a microcapsule dosage for its future development of oral delivery. |
本系統中英文摘要資訊取自各篇刊載內容。