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題 名 | Does Optimized Sperm Penetration Assay Predict Fertility Outcome?=精子穿透卵子檢驗法是否能預測懷孕結果? |
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作 者 | 邱叡坤; 陳雯; 邱燕坤; | 書刊名 | 中華民國婦產科醫學會會刊雜誌 |
卷 期 | 38:3 1999.09[民88.09] |
頁 次 | 頁87-95 |
分類號 | 415.8616 |
關鍵詞 | 精子穿透測試; 懷孕; Sperm penetration assay; Pregnancy; Fecundity; |
語 文 | 英文(English) |
中文摘要 | 目的:精子穿透卵子能力的檢驗是目前檢查男性不孕症原因的一個重要項目。精子穿透力測試(SPA)異常的病人,一般認為是精子有功能上的缺陷而缺乏自然懷孕的能力。我們分析SPA結果及臨床上成功受孕的相關性。 方法:用問卷方式調查244位接受SPA測試的病人,問卷的內容包括懷孕結果,男性及女性不孕之因素,不孕症之治療方式等。115位病人(47%)回答了問卷,作為本文分析的資料。 結果:53%正常SPA測試結果的病人和48%異常SPA測試的病人,其配偶有成功的懷孕。若去除以體外受精技術懷孕的病人,成功的自然受孕率在正常SPA之配偶為48%,異常SPA之配偶為 44%;若再去除精索靜脈曲張手術的病人,配偶成功受孕率在正常SPA之病人為49%,異常 SPA之病人為35%,兩組在統計上沒有顯著的差異。 結論:配偶懷孕率在精子穿透力測試正常與異常病人之間沒有統計上顯著的差異。SPA異常的程度與配偶懷孕率也沒有顯著的相關性。我們建議慎用這測試方法及避免用SPA異常來預測配偶懷孕的可能性。 |
英文摘要 | OBJECTIVE: The sperm penetration assay (SPA) has been recommended to assess sperm function. Patients with abnormal SPA are generally regarded as having a functional defect of the sperm and having poor fertility potential. To clarify this assumption, we examined the clinical fertility outcome of patients with SPA. METHODS: We sent a questionnaire to 244 patients who had SPA (TEST-yolk buffer optimized method) performed in our laboratory. The outcome of pregnancy, other male and female factors for infertility, and treatments were addressed. One hundred and fifteen completed questionnaires (47%) were returned and constituted the data base for this report. RESULTS: Overall, 53% of patients with normal SPA (sperm capacitation index, SCI≧5, n=57)and 48% of patients with abnormal SPA (SCI<5, n=58) achieved pregnancy. Excluding pregnancies resulting from in vitro fertilization, the pregnancy rates are 48% for those with normal SPA (n=52) and 44% for those with abnormal SPA (n=54). When patients who had varicocele ligtion (n=17) were also excluded from analysis, 49% of patients with normal SPA (n=49) and 35% of patients with abnormal SPA (n=40) achieved pregnancy. None of the differences were statistically significant. In addition we could not detect correlation between the degree of SPA abnormality and the pregnancy outcome. CONCUUSIONS: We were unable to demonstrate a correlation between abnormal SPA and clinical fertility outcome. Furthermore, we could not identify a cut off value of SCI below which it is highly unlikely that fertility will occur. Based on these results we recommend cautious clinical application of SPA results to guide treatment decisions. |
本系統中英文摘要資訊取自各篇刊載內容。