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題名 | Ethambutol-Induced Psychosis: A Case Report=Ethambutol造成精神症:一病例報告 |
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作者 | 許健威; 朱國安; 陸悌; 賴瑞生; 盧朝勇; Hsu, Chien-wei; Chu, Kuo-an; Lu, Ti; Lai, Ruay-sheng; Lu, Jau-yeong; |
期刊 | 中華醫學雜誌 |
出版日期 | 19991000 |
卷期 | 62:10 1999.10[民88.10] |
頁次 | 頁724-727 |
分類號 | 418.2219 |
語文 | eng |
關鍵詞 | 精神症; 結核病; Ethambutol; Psychosis; Tuberculosis; |
中文摘要 | Ethambutol是治療結核病的第一線用藥,常見的副作用有眼球後神經炎(retrobulbar neuritis),而其它副作用如白血球和血小板減少、發燒及關節疼痛等則較少見,至於精神方 面的異常就更為少見。我們報導1例疑似結核性肋膜炎的病人,在使用ethambutol後產生躁 動不安、幻視、幻聽及被迫害妄想等精神方面之症狀。藥物停止後,所有精神症狀都消失。 再使用ethambutol時,相關的精神症狀會再度復發,停用後又再度消失。期間未使用其它可 能造成精神症之藥物。在文獻上有關抗結核藥物引起精神症的報導,大部份是因isoniazid 而引起,僅有一篇疑似ethambutol引起的。 |
英文摘要 | Clinically, ethambutol (EMB)-induced psychosis is rare. In our review of the literature, most cases of antituberculosis agent-associated psychoses were caused by isoniazid (INH). We report the case of a 51-year-old man with suspected tuberculosis (TB) pleurisy. An anti-TB trial with INH, rifampicin and EMB was given initially. Dizziness, disorientation, and auditory and visual hallucinations developed after seven days of therapy. Laboratory examinations, including routine biochemistry tests, serum titer of antinuclear antibodies, cerebrospinal fluid analysis and computerized tomography of the head showed no abnormal findings. Following discontinuation of anti-TB agents, the same psychiatric symptoms recurred, but resolved again after discontinuation of EMB. It is important to be aware that EMB can induce psychosis when anti-TB medications are prescribed. aware that EMB can induce psychosis when anti-TB medications are prescribed. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。