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頁籤選單縮合
題名 | Analysis of Prognostic Factors in Chinese Women with Breast Cancer in Southern Taiwan=南臺灣婦女乳癌預後因子之分析 |
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作者 | 陳俊名; 張宏泰; 莫景棠; 劉絮穎; 蔡正中; 周楠華; 王炳惠; 陳以書; | 書刊名 | 中華醫學雜誌 |
卷期 | 62:10 1999.10[民88.10] |
頁次 | 頁717-723 |
分類號 | 416.226 |
關鍵詞 | 無病存活率; 早期乳癌; 整體存活率; 預後因子; Disease-free survival; Early-stage breast cancer; Overall survival; Prognostic factors; |
語文 | 英文(English) |
中文摘要 | 背景 本研究對近7年來在高雄榮民總醫院被診斷為早期乳癌之婦女作回顧分析, 並根據整體存活率及無病存活率來評估其預後因子。 方法 在1990年10月至1997年12月間,共有332位婦女被診斷為早期乳癌,並接受 手術治療。我們使用柯氏多變項迴歸分析,嘗試找出對整體存活率及疾病復發率有意義之預 後因子。 結果 早期乳癌病患之5年累積存活率為88.35%。與整體存活率有關的預後因子,包 括較差之組織細胞分化、淋巴腺轉移數目在4個以上及黃體素接受體為陰性。而與疾病復發 相關之因子,包括陽性之淋巴腺轉移、腫瘤染色體為不成雙套數及組織細胞分化較差。 結論 本研究發現,沒有任何單一的預後因子可以決定乳癌病患的整體狀況,然而綜合 淋巴腺轉移情形、腫瘤染色體套數、組織細胞分化及黃體素接受體狀態,可協助我們推測病 患的預後,並訂出完善的治療計劃。 |
英文摘要 | Background. We conducted a retrospective review of all early-stage breast cancer patients treated at the Veterans General Hospital-Kaohsiung to determine overall and disease-free survival rates, and to evaluate prognostic factors for these outcomes. Methods. During the period of October, 1990, to December, 1997, 332 patients with early-stage breast cancer were treated at our institution. Cox's multivariate regression analysis was used to select prognostic factors significant for overall survival and disease-free survival. Results. The survival rate form breast cancer patients was 88.35% at five years. Prognostic factors predicting brease cancer mortality included poorly differentiated histologic grade, four or more lymph nodes positive for metastasis and negative progesterone-receptor status. For disease recurrence, prognostic factors included positive nodes, aneuploidy and poorly differentiated histologic grading. Conclusions. We conclude that a combination of lymph node status, DNA ploidy, histologic grading and progesterone-receptor status help to evaluate the possible outcomes for patients with breast cancer and to plan for optimal therapy. |
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