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題 名 | Lack of Association between Deletion Polymorphism of the ACE Gene and Ischemic Vascular Diseases in a Chinese Population in Taiwan=血管緊縮素轉化酶基因的刪除多形性現象與臺灣之中國人的缺血性血管疾病缺乏關連 |
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作 者 | 林瑞榮; 樂國柱; 韓鴻志; 張達政; 張昌堯; 葉永祥; | 書刊名 | 中華醫學雜誌 |
卷 期 | 62:11 1999.11[民88.11] |
頁 次 | 頁756-763 |
分類號 | 415.92 |
關鍵詞 | 血管緊縮素轉化酶; 中國人; 基因; 缺血性腦血管疾病; 缺血性心臟疾病; 多形性; 臺灣; Angiotensin I-converting enzyme; Chinese; Gene; Ischemic cerebrovascular disease; Ischemic heart disease; Polymorphism; Taiwan; |
語 文 | 英文(English) |
中文摘要 | 背景:遺傳因子在腦血管疾病之致病機轉上扮演重要角色。本實驗之設計是以生長在臺灣之中國人為研究對象,研究血管緊縮素轉化�t(ACE)基因之刪除/插人多形性現象與中國人缺血性血管疾病之關連。 方法:本實驗共搜集400位缺血性血管疾病病患,包括214位缺血性腦血管疾病病患、186位缺血性心臟病病患及200位無缺血性血管疾病之成人(對照組)。 結果:與對照組相比,缺血性腦血管疾病及缺血性心臟疾病病患均有較高的ACE基因之D/D基因型(22%,20%比16%)及刪除多形性(43%,42%比39%)比例。但以卡方分析,卻未達統計學意義(p>0.05)。更進一步分析刪除多形性比例在性別、年齡上之差異,結果發現亦未有任何一組顯示有統計學意義。 結論:ACE基因之刪除或插入多形性現象和生長在臺灣之中國人的缺血性血管疾病並無關連。缺血性血管疾病之致病機轉是否由其它基因的單一或協同效應所造成,則有待進一步之探討。 |
英文摘要 | Backgroud: The association between deletion/insertion polymorphism of the angiotensin I-converting enzyme (ACE) gene and ischemic vascular diseases (IVDs) is still unclear. This study was designed to evaluate the role of ACE gene polymorphism in the pathogenesis of IVDs in a Chinese population living in Taiwan. Methods: A case-control study was carried out to examine the association of the ACE gene genotype and the allele frequency in 400 IVD patients, including 214 patients with ischemic cerebrovascular disease (ICVD) and 186 patients with ischemic heart disease (IHD), compared with 200 control individuals. Results: Although the patients with ICVD and IHD were found to have higher frequencies of the D/D genotype (22% and 43%) and the D allele (20% and 42%) than the controls (16% and 39%), the statistical differences were not significant, as shown by X�� analysis (p>0.05). Upon further comparison of the frequencies of the D allele among the two sexes and different age subgroups, there was still no significant association. Conclusions: Deletion polymorphism of the ACE gene was not associated with IVD in a Chinese population in Taiwan. The unique or synergistic effect of other genes that might contribute to the pathogenesis of IVDs needs further investigation. |
本系統中英文摘要資訊取自各篇刊載內容。