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頁籤選單縮合
題 名 | 中藥黃芩素延長移植心臟存活期的研究=Prolongation of Cardiac Allograft by Baicalein |
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作 者 | 王水深; 朱樹勳; 黃慧貞; | 書刊名 | 中醫藥年報 |
卷 期 | 16:2 1998.05[民87.05] |
頁 次 | 頁209-220 |
分類號 | 414.33 |
關鍵詞 | 心臟移植; 排斥; 黃芩素; Heart transplantation; Rejection; Baicalein; |
語 文 | 中文(Chinese) |
中文摘要 | 黃芩素可以抑制血管平滑肌的增生,並可對抗手術後的發炎反應,有 抗氧化清除自由基等作用,理論上應可延長移植器官的存活期。本研究的 主要目的在探討中藥黃芩素可否延長移植心臟的存活期。 我們利用重約200-300克的同族(inbred strain)雄性大鼠做實驗,以 Brown-Norway大鼠做心臟接受者,以Brown-Norway和Lewis大鼠交配之第一 子代(F1)做心臟捐贈者。心臟移植方法依Sun lee進行腹部異位心臟移植, 手術後,每天早上、中午、晚上各一次觸診此移植心臟跳動情形。動物實 驗分兩組:實驗大鼠自移植前一天開始肌肉注射黃芩素50 mg/kg。手術後 持續注射至排斥為止,對照大鼠則自前一天開始注射同容積的生理食鹽 水,亦持續注射至排斥為止。一旦移植心臟停止跳動後,便犧牲此大鼠, 抽取血液做生化檢查,然後取下移植心臟做病理切片。 十隻接受黃芩素50 mg/kg注射的大鼠,移植心臟的存活期為10.2±2.6 天。另外十隻接受同容積(1.0毫升)的生理食鹽水注射的大鼠,移植心臟 的存活期為8.7±2.7天。兩組間的存活期並無明顯的差異(p=0.10)。兩組 之生化檢查顯示並無明顯差異,皆無肝、腎等器官之毒性。而GOT、CK、 CK-MB在兩組皆異常升高,顯然和心臟受排斥傷害造成心肌變性壞死有 關。 本實驗利用黃芩素在每天肌肉注射50mg/kg劑量下,無法顯著延長移 植心臟的存活期。若和其他免疫抑制劑合用,是否可以延長移植心臟的存 活期,則有待進一步研究。 |
英文摘要 | Baicalein is a flavonoid from the Chinese herb Scutellaria baicalensis. It had antiproliferative and lipogenase-inhibitory activities. By direct inhibition of growth-related signal, protein kinase, as well as reduction of mRNA expression of platelet-derived growth factor, cell proliferation was inhibited. In this study the effect of baicalein to prolong the survival of cardiac allograft was investigated. Male inbred rats weighing 200-300 grams were used for study. Brown-Norway(BN) rats were used as recipients, with (Lewis X BN) F1 rats as donors. Abdominal heterotopic heart transplantation was performed with microsurgical technique. After transplantation the experiment group received baicalein 50 mg/kg intramuscualr injection every day until rejection. The control group received the same volume (1.0 ml) normal saline intramuscular injection every day until rejection. Rejection was defined as stop of beating of the allograft. The allograft was palpated three times a day, ie. in the morning, at noon, and in the evening. When the transplanted heart stopped beating, the rats were sacrificed. The blood was collected for renal function, liver function, complete blood cell count, creatine kinase (CK), and CK-MB studies. The heart, liver and kidney also received pathological examinations. The survival of the ten transplanted BN rats receiving daily baicalein 50 mg/kg injection was 10.2±2.6 days. The survival of another ten transplanted BN rats receiving normal saline injection was 8.7±2.7 days. The difference between the two groups was not statistically significant (p=0.10). No deterioration of liver or kidney functions was noted in both groups. Abnormally elevated GOT, CK, and CK-MB values were noted in both groups, which might be due to degeneration and destruction of myocytes from severe rejection. With a daily intramuscular injection dose of 50 mg/kg, baicalein did not prolong the survival of cardiac allograft in a model of (Lewis x BN) F1 to BN rats. Because baicalein can inhibit the proliferative response and has anti-inflammatory activity, and is also a free radical scavengen, it may be very useful in cardiac transplantation. Therefore we will perform further study to investigate its concomitant use with other potent immunosuppressive agent to prolong the survival of the cardiac allograts. |
本系統中英文摘要資訊取自各篇刊載內容。