頁籤選單縮合
題 名 | Recent Developments in CD8狇T-Lymphocyte Memory Research=毒殺型淋巴球免疫記憶研究的近期發展 |
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作 者 | 孔祥智; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 98:11 1999.11[民88.11] |
頁 次 | 頁736-739 |
分類號 | 414.82 |
關鍵詞 | 毒殺型淋巴球; 免疫記憶; CD8狇T cell; Immunologic memory; Cytotoxicity; Class I major histocompatibility; Complex antigen; Interleukin 15; T-cell receptor transgenic mice; |
語 文 | 英文(English) |
英文摘要 | Appropriately activated CD8�劫 cells differentiate into cytotoxic effectors capable of eliminating cancer cells and virally infected cells. Successful generation and maintenance of effective CD8 �� T-cell memory, through either natural infection or through vaccination, establishes long-term protection against various pathogenic agents and, therefore, contributes significantly to our health. This report is a review of recent advances in CD8 �� T-cell memory research. The pool of memory CD8 �� T cells is maintained through a mechanism of rapid turnover that is antigenindependent, class I major histocompatibility complex (MHCI) antigen-dependent, and, potentially, IL-15-dependent. Memory CD8 �� T cells, in marked contrast to naive CD8 �� T cells, constitutively express cytotoxic effector function in the absence of antigen stimulation. Furthermore, the vast majority of activated CD8 �� T cells in mice infected with lymphocytic choriomeningitis virus are antigen-specific, prompting revision of the commonly held view that many antigen-nonspecific CD8 �� T cells are activated in response to viral infection. These newly published results not only provide exciting insights into the inner workings of CD8 �� memory maintenance, but they also establish a sound foundation for future investigation. As more detailed molecular and cellular mechanisms of the regulation of memory CD8 �� T-cell survival emerge, the most exciting challenge will be to apply this understanding toward the rational design of vaccines and immunotherapies. These potentials are even more relevant in view of the critical nature of CD8 �� T cells in combating viral infection and cancer, and the relative paucity of effective drugs against these diseases. |
本系統中英文摘要資訊取自各篇刊載內容。