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頁籤選單縮合
題名 | Tumor Immunology--When a Cancer Cell Meets the Immune Cells=腫瘤免疫學:腫瘤細胞與免疫細胞的交互作用 |
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作者姓名(中文) | 許博欽; 許世明; 何弘能; 林榮華; 黃思誠; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 98:11 1999.11[民88.11] |
頁次 | 頁730-735 |
分類號 | 414.82 |
關鍵詞 | 腫瘤免疫學; 腫瘤細胞; 免疫細胞; Tumor immunology; Immune escape; Immune surveillance; |
語文 | 英文(English) |
英文摘要 | Tumor immunology consists of two essential concepts: immune surveillance, which specifies the host immune reactions against tumor cells, and tumor immune escape, which refers to the tumor-cell evasion process against the host immune system. Effective antitumor immunity by the host immune surveillance is supposed to be dependent on the identification of tumor antigens. In the process of malignant transformation, genetic mutations with aberrant expression of cancer-related genes and protein products are potentially immunogenic, which may serve as rejection antigens. Several scenarios are proposed to be responsible for tumor immune-escape mechanisms. The elucidation of the immune deficit against cancer progression has been a difficult task and no solitary mechanism explains the complicated cancerhost immune interactions. Cancer cells may overcome immune surveillance through a common but effective pathway, either by changing the polarity of effector cells, thus down-regulating the proliferation of tumor-specific cytotoxic T cells, or altering the effector compositions of immune cells within the tumor milieu, or both. Understanding the interaction between cancer cells and host immune cells within the tumor milieu is of importance for further clinical applications of immunotherapy in cancer treatment. |
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