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題名 | Acute Fish Liver Intoxication: Report of Three Cases=急性魚肝中毒:三例報告 |
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作 者 | 邱耀堃; 張賴妙珣; 何宜承; 陳靖博; | 書刊名 | 長庚醫學 |
卷期 | 22:3 1999.09[民88.09] |
頁次 | 頁468-473 |
分類號 | 418.88 |
關鍵詞 | 急性維生素A過量症; 魚肝; 鱸科; 脫皮; Acute hypervitaminosis A; Fish liver; Grouper; Desquamation; |
語文 | 英文(English) |
中文摘要 | 食用少數較大體型的魚類例如鯊魚、鮪魚及鱸魚的肝曾被報導會引起一種特殊的 急性中毒症狀包括頭痛及全身脫皮。此種類型的中毒也曾發生在食用鯨、北極熊及海豹等肝 臟。由於這些動物肝臟中含有極大量的維生素A,且這些中毒病人的症狀極類似急性維生素 A中毒,此類型中毒相信是由於過量維生素A所引起。我們在此報告一起因食用大型青藍 鱠(Cephalopholis boenak)魚肝而導致3人急性中毒,其中毒症狀包括:頭暈、頭痛、視力模 糊、噁心、嘔吐、高熱及皮膚脫皮等。其中1位病人症狀極嚴重,除了上述症狀外,甚而有 全身痠痛及表淺性水皰產生。我們給予的治療以支持性療法為主,病人在隨後的門診追蹤, 陸續有手腳脫皮及掉髮等表現。我們觀察到的整個病程頗類似急性維生A中毒或服用類視 色素(retinoids)藥物過量所產生的症狀。急性魚肝中毒極為罕見,尤其在亞熱帶地區。經檢 測此類青藍繪(Cephalopholis boenak)的魚肝含有極大量維生素A。此外這些病人中有2位在 吃魚肝同時配飲清酒,我們認為酒精可能為此中毒之加成因素。 |
英文摘要 | The livers of some larger fish such as shark, tuna and seabass have been reported to be responsible for a peculiar poisoning causing headaches and desquamation. This type of poisoning can also be induced by ingestion of the livers of the sea whale, the polar bear and the seal. Since these animals contain an extremely large quantity of vitamin A in their livers and the symptoms of poisoning in the patients resembled those of patients with acute hypervitaminosis A, the poisoning was believed to have been cused by excessive vitamin A intake. We observed an episode of acute fish liver intoxication in which 3 man experienced dizziness, headache, blurred vision, nausea, vomiting, fever, and desquamation after ingesting the liver of the grouper fish Cephalopholis boenak (C. boenak). One of the patients had full-blown symptoms and presented with a high fever, headache, dizziness, generalized aching pain, and superficial vesicles and bullae of the skin. The treatment was mainly supportive. In the follow-up period, he subsequently developed hair loss and diffuse peeling of the skin on his palms and soles. Acute fish liver intoxication is rare, especially in subtropical regions. Symptomatologically, the clinical pictures of these patients were comparable to acute hypervitaminosis A or retinoid intoxication. The average vitamin A content in the grouper (C. boenak) is high enough to cause acute vitamin A intoxication. Moreover, ethanol may play a potentiating role in this type of event. |
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