頁籤選單縮合
題名 | 繪魚(Cephalopholis boenak)肝油對大白鼠之毒性=Toxicity of the Rockcod, Cephalopholis Boenak, Liver Oil in Rat |
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作 者 | 林美鳳; 黃登福; 鄭弘命; 鄭森雄; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 21:1 1996.02[民85.02] |
頁次 | 頁37-48 |
分類號 | 411.38 |
關鍵詞 | 維生素; 酒精; 繪魚肝油; 毒性; 維生素A過量症; Vitamin A; Alcohol; Rockcod liver oil; Toxicity; Hypervitaminosis A; |
語文 | 中文(Chinese) |
中文摘要 | I992年高雄地區曾發生因一遂飲酒一邊食用鱠魚(Cephalophelis boenak)肝臟而產生類似維生素A過量症之食物中毒事件。為知鱠魚肝臟之毒性是否係高量維生素A所引起,乃以玉米油(控制組)、18萬IU之標準品維生素A、50酒精和鱠魚肝油(含18萬山維生素A)等以口胃管灌方式餵食Wstar系雄性大白鼠,經一天和七天後秤重、解剖,得知高量維生素A之毒作用症狀為導致肝增大,血漿中三酸甘油酯(triglycerides)量之提昇。鱠魚肝油對老鼠之毒作用症狀為體重減輕,肝增大,及血漿中天冬胺酸轉胺基�t(aspartate transaminase)和丙胺酸轉胺基�t(alanine transaminase)等酵素之活性值上昇,但血漿中三酸甘油酯和總膽固醇下降。顯示鱠魚肝油之毒作用症狀與高量維生素A者有所不同。另外,酒精會加重過量維生素A之毒性。 |
英文摘要 | Hypervitarninosis A-like poisoning due to ingesting rockcod (Cephalopholisboenak) liver with drinking wine occurred in Kaohsiung County in February 1992.To investigate the acute toxicity of the rockcod liver, male Wistar rats wereused and fed with corn oil (control group), 180,000 IU of standard vitamin A (retinyl palmitate form), 50 ethanol and liver oil (containing 180,000 IU of vitamin A) of C. boenak. Results indicated that excess doses of vitamin A induced enlargements of liver and high levels of plasma triglycerides in rats. Liver oilof C. boenak induced enlargements of liver, but decreases of growth rate andlevels of plasma triglycerides and total cholesterol and increases of aspartatetransaminase and alanine transaminase activities in the plasma of rats. It demonstrated that the toxic effect of liver oil from C. boenak was somewhat differentfrom that of hypervitamin A. Hypervitarninosis A became more serious when anexcess dose of vitamin A was ingested with alcohol. |
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