查詢結果分析
相關文獻
- Endobronchial Metastatic Disease
- Cervical Lymph Node Metastasis from Melanoma of an Unknown Primary Site--Case Report
- Nodular Melanoma--A Thirteen-Year Clinical Experience
- 鼻腔及副鼻竇之惡性黑色素腫瘤
- Osteogenic Melanoma
- MRI of Primary Malignant Melanoma of Urinary Bladder: A Case Report
- 口腔黏膜的惡性黑色素瘤--病例報告
- Malignant Melanoma of the Anorectum
- Primary Anorectal Melanoma: Report of a Case
- Malignant Melanoma Presenting as an Endobronchial Pulmonary Mass--A Case Report and Literature Review
頁籤選單縮合
題名 | Nodular Melanoma--A Thirteen-Year Clinical Experience=結節性黑色素瘤--十三年之臨床經驗 |
---|---|
作者 | 陳怡如; 吳俊穎; 陳榮達; 沈瑞隆; | 書刊名 | 中華皮膚科醫學雜誌 |
卷期 | 17:3 1999.09[民88.09] |
頁次 | 頁200-207 |
分類號 | 415.691 |
關鍵詞 | 黑色素瘤; Nodular melanoma; Predicting factors; Prognosis; |
語文 | 英文(English) |
中文摘要 | 1985至1998年臺中榮民總醫院共診斷有六十五例黑色素瘤,其中十五例為結節性 黑色素瘤。我們及另一位病理醫師調閱病人的病歷及病理切片,接著分析其發生年齡、性別 、腫瘤厚度、侵犯深度、 發生部位及轉移位置。 應用費雪氏檢驗 (Fisher's exact test) 根據結節性黑色素瘤之臨床及病理特性做單變數分析,並以開普林--米爾方法 (Kaplan-Meier method) 畫出其存活曲線 (survival curve)。 本文中結節性黑色素瘤佔原 發性表皮黑色素瘤之第二位,約有 29%。其平均發生年齡為 56.5 歲。最常發生部位在足部 , 最常轉移位置依發生頻率由高而低為淋巴結、 肺部、腦及骨頭。 依貝氏法 (Breslow's method) 計算平均腫瘤厚度為 5.92 毫米,且大部分侵犯深度在克拉克氏 (Clark's level) 第四及第五階。結節性黑色素瘤在初診斷時多半位於末期,有將近半數之患者位於第四分期 。應用費雪氏檢驗之單變數分析得出,較老之發生年齡 (55 歲 ) 及較晚之診斷分期 (第三 及第四分期 ) 皆代表較差之預後。 而性別、腫瘤是否潰爛或有色素沉澱、腫瘤厚度、侵犯 深度皆對預後無影響。 根據存活曲線,其六個月、一年、及三年的存活率分別為 75%、66% ,及 31.3%。 |
英文摘要 | From 1985 to 1998, 65 patients were diagnosed as cutaneous malignant melanoma at Taichung Veterans General Hospital. Fifteen of them were nodular melanoma. We reviewed the medical charts of these patients. The pathological specimens were reviewed independently by another physician. We then analyzed the mean age at onset, sex, tumor thickness, level of invasion, primary tumor location and metastatic sites. Univariate analysis for survival, according to clinical and histologic tumor behaviors, was performed by Fisher's exact test. The survival curve was plotted by Kaplan-Meier method. Nodular melanoma was the second common melanoma in this study and comprised about 29% of them. The mean age at onset of nodular melanoma was 56.5 years. The most commonly involved site was the feet, and the most common metastatic sites, in descending order, were lymph node, lungs, brain and bone. The mean involved depth by Breslow's method was 5.92 mm. Most of the lesions were in Clark's level Ⅳ and Ⅴ. Upon diagnosis, nodular melanoma was usually in advanced stage; nearly half of them were in stage Ⅳ. Univariate analysis of mortality using Fisher's exact test showed that order age at onset (55 years) and an advanced stage at diagnosis (stage Ⅲ, Ⅳ )predicted a poorer prognosis. Sex, ulceration or pigmentation of tumor, tumor thickness and level of invasion showed no significant difference. The 6-month, 1-year and 3-yea survival rates were 75%, 66% and 31.3%, respectively. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。