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題 名 | Incretin-liki Action of Salivary Peptide P-C and Its Reduction in Diabetic Xerostomia=唾液腺胜冴P-C之類Incretin作用與糖尿病性口內乾燥症 |
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作 者 | 木村郁子; 木村正康; | 書刊名 | 中國醫藥學院雜誌 |
卷 期 | 8:3(專刊) 民88.09 |
頁 次 | 頁133-169 |
分類號 | 413.34 |
關鍵詞 | 唾液腺胜冴P-C; 類Incretin作用; 榶尿病性; 口內乾燥症; Salivary peptide P-C; Potentiation of glucose-stimulated insulin release; Depression of arginine-stimulated glucagon release; Incretin; Diabetes; Xerostomia; |
語 文 | 英文(English) |
英文摘要 | Diabetic xerostomia is a serious complication of diabetes. Salivary flow and the protein content of saliva and makedly decreased by the diabetic state. Salivary peptide P-C,a proline-rich peptide comprised of 44 amino acids, has been isolated from human saliva and identified immunohistochemically in the secretory granules and rought endoplasmic reticulum of serous acinar cells of human submandibular glands. The peptide possesses anti-hyperglycemic effects, and particularly affects after feeding. It potentiates glucose-induced insulin release and depresses arginine-induced glucagon release. The physiological positioning of salivary peptide P-C as an incretin and its linkage to diabetic xerostomia are reviewed. |
本系統中英文摘要資訊取自各篇刊載內容。