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題名 | Aspirin三徵--二例報告=Aspirin Triad--Report of Two Cases |
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作者姓名(中文) | 林家裕; 江榮山; 許振益; 朱敬中; | 書刊名 | 中華民國耳鼻喉科醫學雜誌 |
卷期 | 34:4 民88.07-08 |
頁次 | 頁324-326 |
分類號 | 416.87 |
關鍵詞 | Aspirin三徵; 鼻息肉; 鼻竇炎; Aspirin triad; Nasal polyps; Sinusitis; |
語文 | 中文(Chinese) |
中文摘要 | Aspirin 三徵是由aspirin(阿斯匹靈)藥物過敏、氣喘、鼻竇炎及鼻息肉三症狀所 組成。 在西方人已廣為報告討論:但反觀國內均鮮有報告。臺中榮民總醫院在 1998 年經 歷兩病例, 皆因鼻竇炎及鼻息肉至本科求診, 在回溯其病史時發現此兩病例均有因服用 aspirin( 阿斯匹靈 ) 而造成之氣喘。除以鼻竇功能性內視鏡手術來治療鼻竇炎及鼻息內外 並合併胸腔內科來治療氣喘。 |
英文摘要 | Aspirin sensitivity, asthma, and chronic sinusitis with polyposis comprise aspirin triad syndrome. Aspirin sensitivity is determined by a patient history of significant nasal and bronchial symptoms after ingesting aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). The pathological mechanism in aspirin intolerance is through the inhibition of the cyclo-oxygenase pathway of arachidonic metabolism, which results in increased production of leukotrienes and thus causes bronchospasm. Aspirin triad has been widely reported in America and Europe but rarely in Taiwan. We encountered two patients with aspirin triad. They complained of purulent rhinorrhea, aspirin intolerance, asthma, and nasal obstruction. Both of them underwent functional endoscopic sinus surgery (FESS) for the teatment of sinus diseases with removal of nasal polyps. The symptoms of asthma and sinusitis with polyposis then improved without recurrence. |
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