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題 名 | Immunohistochemical Analysis of Nm23-H1 Protein in Bladder Cancer=以免疫組織染色法研究nm23-H1蛋白質在膀胱癌中所扮演的角色 |
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作 者 | 郭俊逸; 江宏; 陳光國; 張心湜; | 書刊名 | 中華醫學雜誌 |
卷 期 | 62:7 1999.07[民88.07] |
頁 次 | 頁411-417 |
分類號 | 415.837 |
關鍵詞 | 膀胱癌; 免疫組織染色法; nm23-H1蛋白質; Bladder cancer; Immunohistochemistry; Nm23-H1 protein; |
語 文 | 英文(English) |
英文摘要 | BACKGROUND: The nm23 gene was first identified from murine K-1735 melanoma cell lines and possesses metastasis-suppressor activity. However, conflicting results concerning the metastasis-suppressor activity of nm23-H1 gene product have been reported in human solid tumors. The significance of nm23-H1 protein in bladder cancer remains to be determined. Therefore, we examined nm23- H1 protein expression immunohistochemically in bladder cancer. METHODS: Formalin-fixed, paraffin-embedded tissue specimens were obtained from 39 patients with primary bladder cancer who had undergone radical cystectomy between 1987 and 1994. The specimens were examined immunohistochemically using a monoclonal antibody to nm23-H1, and the results of immunostaining were compared with clinicopathologic factors and patient survival. RESULTS: Positive nm23-H1 protein expression was confined primarily to the cytoplasm of bladder cancer cells. A higher frequency of nm23-H1 positive expression was seen in higher stage tumors. There was a positive trend for the expression of nm23-H1 protein with the progression of the tumor (p < 0.025). No relationship was found between nm23-H1 protein expression and patients' clinicopathologic factors including age, tumor size, tumor morphology and tumor grade. Furthermore, nm23-H1 protein expression was not correlated with patient survival. CONCLUSIONS: These results suggest that in bladder cancer nm23-H1 protein expression may play an important role in tumor progression rather than in metastasis suppression. |
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