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題名 | Influence of Polymorphism at p53, CYP1A1 and GSTM1 Loci on p53 Mutation and Association of p53 Mutation with Prognosis in Lung Cancer=肺癌病人其p53、CYP1A1、GSTM1基因多態型對p53基因突變之影響以及p53基因突變與預後關係之探討 |
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作者姓名(中文) | 王憶卿; 陳志毅; 王秀仁; 陳星光; 張元衍; 林嬪嬪; | 書刊名 | 中華醫學雜誌 |
卷期 | 62:7 1999.07[民88.07] |
頁次 | 頁402-410 |
分類號 | 415.468 |
關鍵詞 | CYP1A1基因; GSTM1基因; 肺癌; p53基因; 基因多態型; 預後; CYP1A1 gene; GSTM1 gene; Lung cancer; p53 gene; Polymorphism; Prognosis; |
語文 | 英文(English) |
英文摘要 | BACKGROUND: We previously found that the majority (9/11) of p53 tumor suppressor gene mutations in 60 lung cancer patients in Taiwan were small intragenic deletions and nonsense mutations. To gain insights into the possible etiologic factors involved in these mutations and the prognostic significance of p53 gene mutations in lung cancer in Taiwan, we investigated the influence of polymorphism at p53, cytochrome p450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) loci on p53 gene mutation, and the association of p53 gene mutation with prognosis in these lung cancer patients. METHODS: The polymorphism of these genes was determined by polymerase chain reaction followed by restriction enzyme digestion. The Pearson chi 2 test was used to compare allelic distributions between lung cancer patients and controls. The log-rank test was used to assess the significance of the survival differences between patients with and without p53 mutations. RESULTS: There was no significant difference with respect to the genotype distribution of p53, CYP1A1 and GSTM1 polymorphisms between patients with and without p53 mutations, although a tendency toward increasing frequency of the wild- type homozygote genotype of p53 polymorphism was noted in lung cancer patients containing p53 mutations. We further analyzed the association of p53 mutation with prognoses in lung cancer patients for whom postoperative survival data were available. The estimated median survival times for patients with and without p53 mutation were 25 and 28 months, respectively. There was no significant correlation between p53 mutation and survival. CONCLUSIONS: Our data suggest that p53 gene mutation may not be associated with polymorphisms of p53, CYP1A1 and GSTM1 genes, and it may have no significant effect on the prognosis of lung cancer patients in Taiwan. |
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