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題 名 | 肝醣超載現象分子機制之最新模型=The New Model for Molecular Mechanism of Glycogen Supercompensation Phenomenon |
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作 者 | 郭家驊; 許東雄; | 書刊名 | 大專體育學刊 |
卷 期 | 1:1 1999.06[民88.06] |
頁 次 | 頁139-150 |
分類號 | 528.9012 |
關鍵詞 | 肝醣超載現象; 分子機制; 運動生理學; After exercise; Glycogen synthase; GLUT4 gene; Transgenic mice; Hexokinase; |
語 文 | 中文(Chinese) |
中文摘要 | 肝醣超載現象的發現至今已約四十年。在早期運動生理學流行時代,北歐幾個生 理學家以「系統導向」( system approach )研發出提供運動員增加肌肉肝醣儲存的方法 ,但對於肌肉細胞在運動後如何調整肝醣儲存量,仍是個運動科學上難以解答的謎。在生物 化學逐漸被運動科學家使用作為研究工具後,大部份學者開始傾向相信此現象與肌肉細胞內 肝醣合成酵素( glycogen synthase )的活性調節有關。 然而這個流行至今的理論,無法 完全解釋肝醣超載現象在時程上的效應(運動後肝醣合成酵素活性之增加只維持約 1-3 小 時,但肝醣超載現象仍持續進行 1-3 天)。 卻也找不到更適合解釋肝醣超載現象的其他原 因。基於此,筆者開始使用分子生物學與細胞生物學技術導向,觀察運動後肝醣超載的現象 。部份研究成果已成功的解釋大部份目前無法解釋的謎團,其中包括了解釋「為何肌肉細胞 可以依其運動量來儲存相對程度的肝醣」、「進行肝醣超載步驟時運動後低醣時期肌肉如何 強化肝醣儲存機制」等問題。去年筆者與 Dr. John Ivy 為此受邀共同發表回顧文獻於北歐 生理學會,來摘要四十年來運動後肝醣儲存的重要研究演進,並改寫大部分當前既定的運動 後肝醣儲存的理論與觀念( Ivy & Kuo,1998 )。本文也將討論當前全球對運動後肝醣超載 現象在機制上的瞭解與理論上的演進。並主要將針對筆者最近在實驗上的發現(以游泳為運 動模式),整理出運動後肝醣超載現象分子機制之最新模型。 |
英文摘要 | Glycogen supercompensation phenomenon has been discovered for more than forty years. Due to technical restriction, the current understanding in the phenomenon of glycogen supercompensation has only been limited in physiological and enzymological speculations. Physiologists initially predicted that a prolonged muscle glycogen deficiency produced by carbohydrate deprivation floolwing glycogen depleting exercise would potenitate a muscle cell specifically searching for carbohydrate substrate. Although this prediction has turned out to be true and methods were successfully developed to produce a high amount of muscle glycogen storage for aerobic endurance competition, the actual mechanism for the supercompensation phenomenon is still remained to be a mystery. The role of glycogen synthase regulation on post-exercise glycogen supercompensation was intensively investigated during the last two decades. The rate of glycogen resynthesis after exercise did follow the I/I+D ratio of glycogen synthase activity, which perfectly explained the initial rapid phase of post-exercise glycogen resynthesis. However, the glycogen supercompensation phase appears to be less dependent on the I/I+D ratio, since the ratio was returned to control level during the early resynthesis period. Scientists were unable to find out the true explanation for the interesting phenomenon. This article will review the current understanding in the glycogen supercompensation research within last 40 years. Our recent findings have made a major break-through in the understanding of the phenomenon. Part of the evidence will also been presented in the article for proposing the current model of glycogen supercompensation phenomenon. |
本系統中英文摘要資訊取自各篇刊載內容。