頁籤選單縮合
題 名 | Stability of Curcumin in Buffer Solutions and Characterization of Its Degradation Products |
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作 者 | Wang,Ying-jan; Lin,Jen-kun; | 書刊名 | 康寧學報 |
卷 期 | 1:2 1999.03[民88.03] |
頁 次 | 頁119-123 |
分類號 | 435.219 |
關鍵詞 | |
語 文 | 英文(English) |
英文摘要 | The degradation kinetics of curcumin under various pH conditions and the stability of curcuinin in physiological matrices were investigated. When curcumin was incubated in 0.1 M phosphate buffer and serum-free medium, pH 7.2 at 37 (C, about 90% decomposed within 30 min. A series of pH conditions ranging from 3 to 10 were tested and the result showed that decomposition was pH-dependent and occurred faster at neutral-basic conditions. It is more stable in cell culture medium containing 10% fetal calf serum and in human blood; less than 20% of curcumin decomposed within 1 h, and after incubation for 8 h, about 50% of curcumin is still remained. Trans-6-(4'-hydroxy-3'-methoxyphenyl)-2,4-dioxo-5-hexenal was predicted as major degradation product and vanillin, ferulic acid, feruloyl methane were identified as minor degradation products. The amount of vanillin increased with incubation time. |
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