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題名 | Pharmacokinetics of Benzbromarone in Normal Chinese Males=Benzbromarone在健康華人男性體內的藥物動力學 |
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作者 | 許如玉; 許美玉; 許興智; 陳素容; 王一邦; | 書刊名 | 藥物食品分析 |
卷期 | 7:2 1999.06[民88.06] |
頁次 | 頁107-114 |
分類號 | 418.22 |
關鍵詞 | 高效液相層析法; 藥物動力學; 華人; Benzbromarone; HPLC; Pharmacokinetics; Chinese; |
語文 | 英文(English) |
中文摘要 | Benzbromarone為一有效降尿酸藥劑。26名健康男性口服100mg後所得血漿藥物動 力學參數為:C□(3.51±0.90μg/mL, mean±SD),AUC□(0-14h, 17.94±4.53μg.h/mL), total AUC(19.00±4.73μg.h/mL),T□(3.08±1.15h),terminal phase T□(2.97±0.85 h), MRT(5.70±1.25h) and Cl/F(89.5±26.2mL/min)。Wagner-Nelson解析結果該藥在吸收過程 中有代謝反應。若同時評量C□和AUC,或其對數轉換向量,可得90%可信□回,若同時評量 C□,AUC和MRT,或其對數轉換向量,可得90%可信□圓球來描述互為相關的生體可用率參 數的90%可信範圍。 比較benzbromarone在華人和白種人體內的藥物動力學參數值,並未發現有所差異。在 本試驗也未發現在白種人中所具有的對該藥物呈消失遲緩的表型。 |
英文摘要 | Pharmacokinetics of benzbromarone, a potent hypo-uricemics, have been investigated employing 26 normal Chinese males. Following oral administration of 100 mg dose (Desuric 100 mg/tablet, Labaz France), the pharmacokinetics of benzbromarone based on plasma data were C□ (3.51 ± 0.90 μg/mL, mean ± SD), AUC□ (0-14 h, 17.94 ± 4.53 μg.h/mL), total AUC (19.00 ± 4.73 μg.h/mL), T□ (3.08 ± 1.15 h), terminal phase T□ (2.97 ± 0.85 h), MRT (5.70 ± 1.25 h) and Cl/F (89.5 ± 26.2 mL/min). Wagner-Nelson absorption plots of the mean benzbromarone plasma concentrations suggest that there are competing reactions in the absorption process. The 90% confidence regions for C□ and AUC, and for C□, AUC and MRT, and their log- transformed vectors were also estimated. No evidence to show that the pharmacokinetics of benzbromarone in Chinese are different from those reported in Caucasian subjects, and none of the slow elimination phenotype with benzbromarone have been observed in this study. |
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