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題名 | Applications of Acute Phase Reactants in Infectious Diseases=急性期反應物質於感染性疾病之應用 |
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作者 | 邱貞嘉; 卓正宗; Chiou, Chen-chia Christine; Cho, Cheng T.; Johnson,Heather L.; |
期刊 | 微免與感染雜誌 |
出版日期 | 19990600 |
卷期 | 32:2 1999.06[民88.06] |
頁次 | 頁73-82 |
分類號 | 414.8 |
語文 | eng |
關鍵詞 | 急性期反應物質; 感染性疾病; Acute phase reactants; C-reactive protein; Erythrocyte sedimentation rate; Infectious disease; Interleukins; Cytokines; |
中文摘要 | 急性期反應物質(acute phase reactants)之升高是宿主對感染、發炎及組織傷害的非特異性反應,此物質的主要生物功能是重建生物恆定並提高生存的機會。當懷疑怠染或發炎反應時,測定急性反應物質之改變在臨床上幫助很大,像纖維蛋白及補體蛋白等的反應物質在發炎反應中會增加,但此增加值並不高而且對於鑑別診斷或是對治療反應評估並無助益。相反地,C型反應蛋白(C-reactive protein,CRP)在急性侵犯型感染時增高就很顯著,而且可以和發炎或組織傷害的嚴重程度平行關係。這個好處使CRP成為偵測疾病的存在、治療的反應及恢復的結果之有利標誌。 |
英文摘要 | The elevation of actue phase reactants (APRs) is a nonspecific host response to infection, inflammation, and tissue injury. The major biologic function of APRs is to restore homeostasis and to improve survival. Measuring the alterations in APRs can be a useful clinical marker when an infection or inflammatory response is suspected. Serum levels of reactants like fibrinogen and complement proteins increase as part of the inflammatory response, but the increase is trivial and does not contribute to the differential diagnosis or the evaluation of therapeutic responsiveness. By contrast, C-reactive protein (CRP) concentrations increase markedly with acute invasive infections which parallel the severity of inflammation or tissue injury. This advantage makes CRP a useful marker for the presence of disease, response to therapy, and ultimate recovery. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。