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題 名 | Is Serum Transferrin Receptor a Sensitive Marker of Iron Repletion in Patients with Iron-Deficiency Anemia and Hemodialysis Patients?=缺鐵性貧血及長期血液透析患者的血清運鐵蛋白受體濃度是否可作為鐵劑補充治療之指標? |
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作 者 | 侯君正; 吳繡春; 吳肖琪; 陳振文; 楊五常; 吳義勇; | 書刊名 | 中華醫學雜誌 |
卷 期 | 62:4 1999.04[民88.04] |
頁 次 | 頁189-194 |
分類號 | 415.513 |
關鍵詞 | 鐵劑補充; 缺鐵性貧血; 血清運鐵蛋白受體; Iron-deficiency anemia; Iron supplementation; Transferrin receptor; |
語 文 | 英文(English) |
中文摘要 | 背景最近幾年的研究顯示,血清運鐵蛋白的受體濃度可作為診斷缺鐵性貧血之良 好指標。為了維持鐵值的恆定,細胞內之運鐵蛋白受體與血清鐵素呈逆向性調節。本研究的 目的在探討缺鐵性盆血及已接受鐵補充劑之長期血液透析患者,其血清運鐵蛋白受體濃度及 血清鐵素、血清運鐵蛋白飽和度之高低;同時觀察缺鐵性貧血患者在接受鐵補充劑時,血清 運鐵蛋白受體濃度及血清鐵素變化之情形。 方法利用�t聯免疫吸附法測量15位缺鐵性貧血患者,30位已接受鐵補充劑之長期血液透 析患者以及31位健康成人的血清運鐵蛋白受體之濃度。所有患者的血紅素、血比容、紅血 球指標、血清鐵素、血清運鐵蛋白飽和度均受測定。此外還觀察3位接受8-16週鐵劑治 療之缺鐵性貧血患者,其血清運鐵蛋白受體、血清鐵素、血清運鐵蛋白飽和度之一系列變化 。 結果三組患者之年齡及性別並無明顯差異。缺鐵性貧血患者的平均血清運鐵蛋白受體濃度明 顯高於健康成人對照組及接受長期血液透析之患者( 5.6 ± 2.4、 1.8 ± 0.4 及 1.7 ± 0.5 μ g/ml );接受鐵劑治療的缺鐵性貧血患者隨著血色素的上升,其血清運鐵蛋白受體 濃度逐漸下降,而血清鐵素及血清運鐵蛋白飽和度則逐漸升高;血清運鐵蛋白受體濃度的變 化要在4週後才顯著,不似血清鐵素及血清運鐵蛋白飽和度之變化較快速。 結論本研究顯示,在鐵劑補充之過程中,以血清運鐵蛋白受體濃度之變化作為早期指標雖然 顯著,但不及血清鐵素及血清運鐵蛋白飽和度之變化靈敏。 |
英文摘要 | BACKGROUND: Serum transferrin receptor (sTfR) concentration has been recognized as a reliable laboratory indicator of iron deficiency in recent years. But its response to iron supplementation has not been investigated. METHODS: We evaluated the sTfR concentrations in 15 patients diagnosed with iron-deficiency anemia, in 30 patients receiving maintenance hemodialysis (HD) with iron repletion and in 31 healthy controls. The serial changes of sTfR concentration and their correlation with serum ferritin in patients with iron deficiency under iron repletion were also examined in three patients. RESULTS: In patients with iron-deficiency anemia, the sTfR concentration was 5.6 +/- 2.4 mg/ml, significantly higher than that in the control group (1.8 +/- 0.4 mg/ml) and patients receiving maintenance HD with iron repletion (1.7 +/- 0.5 mg/ml). The three patients with iron-deficiency anemia who received eight to 16 weeks of iron supplementation showed steady and significant decreases in sTfR concentration and significant increases in serum ferritin and transferrin saturation. However, the decreases in sTfR concentration did not occur immediately, as did the increases in serum ferritin and transferrin saturation, following iron repletion. There was a four- week delayed response in the decrease of sTfR concentrations as measured against serum ferritin and transferrin saturation. CONCLUSIONS: sTfR concentration may not be as effective as an early index of iron repletion compared with serum ferritin and transferrin saturation. |
本系統中英文摘要資訊取自各篇刊載內容。