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題 名 | Increased Hippocampal Nerve Growth Factor Following Beta-Amyloid Peptide Treatment in Rats=貝他類澱粉蛋白質增加鼠腦海馬迴神經生長因子的含量 |
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作 者 | 陳秀宜; 李正淳; 姜淑芬; | 書刊名 | 中臺灣醫學科學雜誌 |
卷 期 | 4:2 1999.06[民88.06] |
頁 次 | 頁98-103 |
分類號 | 415.149 |
關鍵詞 | 阿滋海默症; 貝他類澱粉蛋白質; 酵素聯結免疫吸收法; 神經生長因子; Alzheimer disease; Beta-amyloid protein; ELISA; Nerve growth factor; |
語 文 | 英文(English) |
中文摘要 | 阿滋海默症之主要病理特徵為大腦皮質及海馬迴累積多量的類澱粉蛋白質斑塊(又名神經斑、老人斑)與神經纖維結,以及該處有大量細胞死亡之現象。許多研究結果顯示貝他類澱粉蛋白質可能對阿滋海默症之病理有相當之重要性。神經生長因子乃維持前腦基底乙醯膽鹼細胞存活之主要營養因子,阿滋海默症病人腦部之細胞死亡,可能與神經生長因子之供應失調有關。本研究係注射貝他類澱粉蛋白質之片段β(25-35)於大白鼠之海馬迴部位,2週後之酵素聯結免疫吸收法(ELISA)測定該部位之神經生長因子含量。結果發現注射β(25-35)之大白鼠的海馬迴,其神經生長因子含量比控制組顯著增加,此與臨床結果一致,顯示神經生長因子與β(25-35)引起之神經退化具有密切之相關性。 |
英文摘要 | Alzheimer disease (AD) is characterized by the presence of beta-amyloid plaque and neurofibrillary tangles as well as cell loss in the cortex and hippocampus. Much evidence suggests that beta-amyloid protein plays a central role in the neuropathogenesis of the disease. Nerve growth factor (NGF) provides critical trophic support for the cholinergic neurons of the basal forebrain. It has been suggested that the neurodegeneration of AD is the result of diminished trophic support. In the present study, the effect of /3 (25-35), a functional peptide fragment of beta-amyloid protein, on nerve growth factor in the hippocampus was examined. Nine nmol of β (25-35) was injected into rat hippocampus while each control animal received a reversed peptide β (35-25) injection. NGF concentration was measured using an enzyme linked immunosorbant assay 2 weeks following the injection. Our results showed that the NGF levels in rats which received β (25-35) injection were significantly greater than those of control rats. These data suggest that NGF may be involved in /3 (25-35) induced neurotoxicity. |
本系統中英文摘要資訊取自各篇刊載內容。