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題 名 | 類毛地黃化合物(蟾蜍毒素)中毒:一急診病例報告及文獻回顧=Digoxin-Like Compounds(Bufotoxin) Intoxication: A Case Report and Literature Review |
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作 者 | 許金旺; 林健盛; 陳建生; 楊久滕; 林昌琦; 劉敏英; | 書刊名 | 醫學研究 |
卷 期 | 19:5 1999.03[民88.03] |
頁 次 | 頁314-322 |
分類號 | 418.8 |
關鍵詞 | 蟾蜍一二烯醇; 類毛地黃化合物; 高血鉀; 毛地黃抗體拮抗劑; Bufodienolide; Digoxin-like compound; Hyperkalemia; Digoxin-specific Fab fragment; |
語 文 | 中文(Chinese) |
中文摘要 | 在臺灣蟾蜍及青蛙有相似外表,因貪食或誤食蟾蜍而致中毒或死亡時有所聞。蟾蜍毒素的主要成分以類脂醇衍化物(steroid derivatives)為主,是一種強心配醣體,具有心臟毒性,在結構上類似毛地黃兩者有免疫交叉反應,視為類毛地黃化合物(digoxin-like compound),兩者生物毒性所產生的臨床特徵相似,中毒現象常見腸胃不適,心搏過緩,心律不整,高血鉀甚或因嚴重房室傳導阻礙或危害生命的心室心搏過速,造成心臟血管崩潰而死亡。本例為一位四十五歲男性,在誤食蟾蜍湯三十分鐘後,陸續地出現類似毛地黃中毒的臨床特徵,並且很快出現致命性心室心律不整,而導致死亡。特就其臨床現象及急診處置提出討論並作文獻回顧。 |
英文摘要 | Toad and frogs have a similar appearance in Taiwan. There have been several reports describing severe biological intoxication and often fatal outcomes after ingestion of toad soup or killed toads. Bufotoxin is a steroid derivative which has similar chemical structure and cross immunoassay reaction to digoxin. The presentation of intoxication could show similar clinical features like those of digoxin overdose including gastrointestinal discomfort, bradyarrhythmia, life-threaten malignant ventricular arrhythmia and hyperkalema. We reported a case of a 45-year-old man progressively presented the similar clinical picture of severe digoxin-like intoxication 30 minutes after ingestion of toad soup. It was followed by malignant ventricular arrhythmia and death four hours later. |
本系統中英文摘要資訊取自各篇刊載內容。