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題 名 | Amoxicillin治療急性中耳炎之效果=Efficacy of Amoxicillin in Treating Acute Otitis Media |
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作 者 | 徐積寬; 蕭彰文; 蕭安穗; | 書刊名 | 中華民國耳鼻喉科醫學雜誌 |
卷 期 | 34:1 民88.01-02 |
頁 次 | 頁1-6 |
分類號 | 416.821 |
關鍵詞 | 急性中耳炎; 積液性中耳炎; 安莫西林; Acute otitis media; Otitis media with effusion; Amoxicillin; |
語 文 | 中文(Chinese) |
中文摘要 | 背景:本研究的目的是為了解amoxicillin在急性中耳炎的臨床療效,並評估其是否仍值得作為第一線治療藥物。 方法:從1995年7月至1997年10月本院與臺北榮民總醫院先後收集急性中耳炎患者共56例,對所有病患施予amoxicillin治療,其劑量為40mg/Kg/day,分每天三次給予。 結果:在全部56例病患中有44例(78.6%)呈現有效的治療效果,另有12例(12.4%)治療失敗。若依年齡層分為A(3個月至2歲,25例)、B(3至6歲,20例)及C(7歲以上,11例)三組,其治癒率分別為68%、85%、91%,三組之間並無明顯統計差異。本研究中共有36例(48耳)接受了鼓室圖追蹤檢查,結果顯示在治療前有31耳(64.4%)出現了中耳積液,而治療後仍有27耳(56.3%)呈現積液現象,須進一步地追蹤及治療。在接受鼓室圖檢查的36例病患中有9例(10耳)亦接受聽力檢查,其治療前後平均氣骨傳導差值分別為14.7及61dB,顯示急性中耳炎所導致的輕度傳音性聽力不良,在治療後略有進步。56例病人在接受amoxicillin治療之後,僅有2例(3.6%)出現明顯的副作用。 結論:我們認為基於療效、價格、副作用及病人接受度等因素來考量,amoxicillin應值得作為治療急性中耳炎的第一線藥物。 |
英文摘要 | Background: To evalwate the clinical efficacy of amoxicillin treatment for patients with acute otitis media, and to determine whether it deserves to be used as a first-line medication in Taiwan. Methods: From July 1995 through October 1997, 56 patients diagnosed with acute otitis media were enrolled in our study. All patients were prospectively studied to evaluate the efficacy of amoxicillin treatment, at dosages of 40 mg/Kg/day, divided into three equal doses. Results: Overall, in the 56 patients treated, amoxicillin showed an efficacy rate of 78.6% (44 out of 56 patients). According to the age differences, 25 patients were classified as group A (3 months to 2 years old), 20 as group B (3 to 6 years old), and 11 as group C (7 years and older). The clinical success rates for these groups were 68%, 85% and 91%, respectively. However, no statistically significant differences existed among the groups. Compared with the occurence rate of otitis media with effusion before amoxicillin treatment (64.4%), the occurence rate after treatment (56.3%) did not significantly decrease. The average air-bone gap was slightly decreased after treatment when compared with that found before therapy (6.1 vs. 14.7 dB). Conclusion: Based on these results, we conclude that amoxicillin is an effective and safe medication. It can therefore be regarded as the first choice of empiric therapy for acute otitis media. |
本系統中英文摘要資訊取自各篇刊載內容。