查詢結果分析
來源資料
頁籤選單縮合
題名 | Indocyanine Green Clearance Test in Non-Cirrhotic Hepatitis Patients: A Comparison and Analysis between Conventional Blood Sampling Method and Finger Piece Monitoring Method=非肝硬化之肝炎病人靛氰藍綠廓清試驗:傳統靜脈採血法與指尖光譜測量法之比較及分析 |
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作 者 | 蘇銘堯; 林灯寅; 沈一嫻; 朱嘉明; 邱正堂; 廖運範; | 書刊名 | 長庚醫學 |
卷期 | 22:1 1999.03[民88.03] |
頁次 | 頁17-24 |
分類號 | 415.533 |
關鍵詞 | 靛氰藍綠廓清試驗; 手指監視系統; 肝炎; Indocyanine green clearance test; Finger piece monitoring; Hepatitis; |
語文 | 英文(English) |
中文摘要 | 背景:青定氰藍綠(ICG)手指監視系統是種非侵襲性測量血中ICG濃度的方法, 相較於傳統靜脈採血法之須多次採血,此法提供了另種非侵襲性檢查的選擇。本研究之目的 在於探討非肝硬化之肝炎病患以手指監視系統與傳統靜脈採血法之差異的比較與分析。 方法:我們總共收集了44男12女,共56個肝炎且非肝硬化病患,平均年齡是38.27±14.20歲 。 每一個病人均檢測傳統的肝生化檢驗, 胎兒蛋白( AFP ), 凝血�t原時間( Prothrombin time ),以及以手指監視系統與傳統靜脈採血法測得之 15 分後 ICG 的滯留 比率與廓清率。 結果:15分後ICG的滯留比率,以抽血法測得之bR15為28.49±23.74%;比ICG手指監視系統 之 fR15 為 32.83 ± 23.99 %稍低, 兩者之間有極佳之相關性存在( r = 0.944,p = 0.0002 ); 而 ICG 之廓清率以採血法之 bK 值為 9.16 ± 5.00 %比指尖光譜測量法之 fK 值 11.24 ± 3.56 %稍低, 同樣也有很好的相關性( r = 0.721,p = 0.0003 )。 再進一步分析 fR15 與肝生化檢查之間的關係: 膽色素( bilirubin )≧ 3mg ╱ dl 之 fR15 為 49.71 ± 26.22 %,而反之其 fR15 為 22.23 ± 13.48 %( p = 0.0039 ); 胎兒蛋白≧ 100ng ╱ ml 之 fR15 為 61.96 ± 15.84 %,AFP < 100ng ╱ ml 為 28.52 ± 21.74 %( p = 0.0062 ); 凝血�t原時間延長≧ 3 秒之 fR15 為 71.46 ± 16.80 %,其餘為 29.03 ± 21.06 %( p = 0.0046 ); 再比較此三項檢查皆正常或僅一項異 常之 fR15 為 33.71 ± 19.30 %,二項以上異常者為 71.04 ± 14.83 %;此二組之值在 統計學上具有顯著的差異( p = 0.0002 )。 結論:在肝炎病患而言,以ICG手指監視系統和抽血分光光度檢法所得的結果之間有很好的 相關性;而且在評估肝功能上與肝生化檢查有良好的一致性,值得臨床上使用來評估肝炎病 患之肝功能。 |
英文摘要 | Background: The indocyanine green (ICG) Finger Piece Monitor system is a non-invasive method for measuring blood ICG concentrations for the evaluation of hepatic function. This study was conducted to determine its clinical usefulness in non-cirrhotic patients. Methods: Traditional liver function tests, alpha-fetoprotein, prothrombin time, and ICG clearance tests, by both blood sampling method and Finger Piece Monitoring method were performed simultaneously on 56 non-cirrhotic hepatitis patients. The plasma clearance rate (K) and 15-minute retention ratio (R15) of ICG were analyzed and compared with traditional liver function test results. Results: The clearance rate using the Finger Piece Monitoring method was slightly lower than that of the blood sampling method (9.16 ± 5.00%/min vs. 11.24 ± 3.56%/min) with good correlation (r=0.721, p=0.0003). The 15-minute retention ratio using the Finger Piece Monitoring method showed better correlation with blood sampling method (32.83 ± 23.99% vs. 28.49 ± 23.74%, r=0.944, p=0.0002). Analysis between traditional laboratory tests and fR15 revealed a higher fR15 value in patients with bilirubin-total-T ≧ 3mg/dl (49.71 ± 26.22% vs. 22.23 ± 13.48%), alpha-fetoprotein ≧ 100ng/ml (61.96 ± 15.84% vs. 28.52 ± 21.74%), and PT prolongation ≧ 3sec (71.46 ± 16.80% vs. 29.03 ± 21.06%). Conclusion: There is a good correlation between the conventional blood sampling method and the ICG Finger Piece Monitoring system method. The ICG Finger Monitoring system provides an alternative for traditional laboratory tests for the evaluation of hepatic dysfunction in hepatitis patients. |
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