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題名 | 氨基菲林對大白鼠鼻唇肌與顏面神經呼吸活動之影響=Changes in Respiratory-Related Activities of the Alae Nasi Muscle and Facial Nerve after Aminophylline Treatment in the Rat |
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作者 | 廖娟妙; 張振隆; 杜小玲; 黃基礎; Liao, Jiuan-miaw; Chang, Chen-lurng; Duh, Sheau-ling; Hwang, Ji-chuu; |
期刊 | 中山醫學雜誌 |
出版日期 | 19990100 |
卷期 | 10:1 1999.01[民88.01] |
頁次 | 頁59-69 |
分類號 | 414.5 |
語文 | chi |
關鍵詞 | 氨基菲林; 顏面神經吸氣活動; 膈神經吸氣活動; 鼻唇肌肌電圖; 膈肌肌電圖; Aminophyllin; FNA; PNA; AN EMGs; Dia EMGs; |
中文摘要 | 本研究之主要目的在探討氨基菲林(aminophylline:AP)對大鼠鼻唇肌與顏面神經呼吸活動的影響。大鼠經urethane麻醉(1.2g/kg i.p.),切斷兩側迷走神經後分成兩組,一組採自然方式呼吸(spontaneously breath),以便記錄鼻唇肌和膈肌的呼吸活動,另一組以gallamine triethiodide(5 mg/kg i.v.)將肌肉予以麻痺,以人工呼吸機維持生命,呼氣末氣體濃度維持在高氧(hyperoxia)及二氧化碳濃度正常(normocapnia)情況下進行實驗。使用靜脈注射(i.v.)方式給藥,觀察注射AP後第1、2、3、5、10、20、30與60分鐘的呼吸活動變化。低劑量AP(4 mg/kg b.w.)在注射後第3分鐘促使鼻唇肌呼吸活動增加為注射前的109%(p>0.05),於第20分鐘增加為120 %(p>0.05),膈肌的反應是注射後第3分鐘增加為注射前的105%(p>0.05);顏面神經的呼吸活動於第3分鐘增加為注射前的119%(p>0.05),第20分鐘增強為134%(p<0.05),於第30分鐘的增強作用達到最大,為注射前平均高度之142%(p<0.05),膈神經活動的反應在第3分鐘增加為注射前的106%(p>0.05);高劑量AP32mg/kg b.w.處理後,在第1-3分鐘立即使鼻唇肌與膈肌呼吸活動增強,分別增加為注射前的181%(p<0.05)及110%(p>0.05),於第10分鐘開始下降,但仍高於注射前的平均高度;顏面神經與膈神經在第1-3分鐘的呼吸活動明顯增強為167%(p<0.05)與119%(p<0.05),並於第30分鐘達到最高,分別為注射前之199%(p<0.05)與127%(p<0.05)。AP對呼吸頻率(f)或吸氣時間(TI)之影響並不顯著,但有輕微降血壓的作用。綜合以上結果:AP可增加鼻唇肌與膈肌的吸氣活動,亦可促進顏面神經與膈神經放電,鼻唇肌與顏面神經吸氣活動對AP的反應遠大於膈肌與膈神經。這些結果顯示對鼻腔段所屬上呼吸道阻塞的病人有所助益。 |
英文摘要 | The purpose of the present study was to evaluate the responses of electromygram activities (EMGs) of the alae nasi (AN) muscle and respiratory-modulated facial nerve activities (FNA) to bolus injection of aminophylline (AP). Adult rat was anesthetized with urethane (1.2g/kg) and vagotomized bilaterally. The animal ws seperated into two groups. The first group was spontaneously breathed through a tracheal tube for EMG sdudy. The second group was paralyzed and artificially ventilated. End-tidal fractional concentration of CO2 was mantained at normocapnia in hyperoxia. Changes of AN EMGs and FNA at the particular time intervals (1、2、3、5、10、20、30 and 60 minute) was observed after AP treatment. Results showed that the increase of respiratory activities were found from the 2th or 3th minute. With a low dose of AP (4mg/kg), AN EMG was increased to 109% of control, Dia EMG to 105%, FNA to 119%, and phrenic nerve activities (PNA) to 106% (p>0.05) at the third minute respectively. FNA was further increased to a level of 134% (p<0.05) at 20th minute, and to 142% (p<0.05) at 30th minute. With a high dose of AP (32mg/kg), the increase of AN and Dia EMGs reached a peak level to 181% (p>0.01) and 110% (p>0.05) at the 1-3 minute. After the peak activities, these two muscles were gradually recoveried to normal levels. Yet, AN EMGs was still higher than that of control. FNA and PNA also reached a level of 167% (p<0.05) and 119% (p<0.05) at 1-3 minute after AP treatment, and were further enhanced to a peak level of 199% (p<0.05) and 127% (p<0.05) at the 30 minute respectively. NO significant changes in rspiratory frequency (f) and inspiratory duration (TI) were found with either dose of AP. The arterial blood pressure was substantially decreased after the adminstration of a high dose of AP, but no significant change with a low dose of AP infusion. These results indicate that AP could produce an excitatory action upon AN, Dia, FNA, and PNA. The enhancement of AN EMGs or FNA response was much more than that of Dia EMGs or PNA. According to our results, aminophylline might be beneficial to patients with upper airway (particular nasal segment) obstruction. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。