頁籤選單縮合
題 名 | Repeated Significance Testing with Censored Rank Statistics in Interim Analysis of Clinical Trials |
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作 者 | Gu,Minggao; Lai,Tze Leung; | 書刊名 | Statistica Sinica |
卷 期 | 8:2 1998.04[民87.04] |
頁 次 | 頁411-428 |
分類號 | 319.5 |
關鍵詞 | Censored survival data; Clinical trials; Group sequential tests; Rank statistics; Stopping rules; Use function; |
語 文 | 英文(English) |
英文摘要 | A simple class of stopping rules is introduced for time-sequential rank tests to compare time to failure between two treatment groups, such as in the case of a clinical trial in which patients enter serially and in which interim analyses of the data are performed periodically so that the trial may be stopped early when one treatment is found to be significantly better than the other. These time-sequential rank tests are shown to achieve both savings in study duration and increase in power over their nonsequential counterparts, and provide a simple but statistically efficient method to circumvent the difficulty of “calendar time” versus “information time” in the design of group sequential trials with failure-time endpoints. |
本系統中英文摘要資訊取自各篇刊載內容。