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頁籤選單縮合
題 名 | Echo-Enhancing Sonography of Hepatic Tumors=肝臟腫瘤之回音增強超音波檢查 |
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作 者 | 周宜宏; 李三剛; 周定遠; 邱宏仁; 許重權; 刁翠美; 曾修山; 姜仁惠; 于俊; | 書刊名 | Journal of Medical Ultrasound |
卷 期 | 6:3 1998.09[民87.09] |
頁 次 | 頁123-129 |
分類號 | 415.5093 |
關鍵詞 | 肝臟腫瘤; 超音波檢查; Ultrasound contrast medium; Hepatoma; Neoplasm; Liver; |
語 文 | 英文(English) |
英文摘要 | Background: A phase Ⅲ clinical trial was conducted to evaluate the echoenhancing effects of a new ultrasound contrast medium, SH U 508 A, in hepatic tumors. Materials and Methods: Thirty-three patients with 57 hepatic nodules (1-5 cm in diameter; mean ± SeM, 2.4 ± 1.3 cm) were enrolled in this study. Twenty-four patients had hepatocellular carcinoma (HCC; 34 tumors) and nine patients had hepatic metastasis (23 tumors). Doses of 200, 300 or 400 mg/ml, respectively (6.5, 8.5 or 12.5 ml), of SH U 508 A were administered intravenously. The echo-enhancing effects were documented by using both a video recorder and a magneto-optical disk. An HDI 3000 system or a GP 8500 system with power Doppler ultrasound were applied to each nodule before and after contrast media injection. Results: The transit time for an enhancing effect was 10-18 seconds. Optimal viewing time was 50-220 seconds and washout time was 6-12 minutes. Echoenhancing effects were noted in 100% (34/34) of HCCs and 87% (20/23) of metastatic nodules, a total of 95% (54/57) positive enhancement. Different grading of enhancement was also observed between HCC and metastasis. Better enhancement was seen in HCC (82% ≧ Grade 2 vs 30% in metastasis; p<0.001). Conclusion: Echo-enhanced liver ultrasound with SH U 507 A can improve power Doppler ultrasound images. Tumor vascularity can be better demonstrated. The use of SH U 508 A may contribute to treatment planning and improve confidence in diagnosis of hepatic tumors. |
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