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頁籤選單縮合
題名 | 以骨生化代謝指標探討老年人口骨質代謝情形=An Evaluation of Bone Turnover Rate by Assessing Bone Biochemical Markers in the Elderly |
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作者 | 胡中傑; 唐憶淨; 賴文恩; 王玉潯; | 書刊名 | 中華民國家庭醫學雜誌 |
卷期 | 8:4 1998.12[民87.12] |
頁次 | 頁192-202 |
分類號 | 415.596 |
關鍵詞 | 骨生化代謝指標; 老年人; 骨質代謝; Osteoporosis; Bone biochemical marker; Elderly; |
語文 | 中文(Chinese) |
中文摘要 | 骨代謝速率的上昇,代表骨質流失的速度加快,引起骨質疏鬆症的機會增加,因而發生骨折的可能亦隨之提高。隨著骨生化代謝指標臨床應用被確立,本研究透過分層隨機抽樣方法,以骨生化代謝指標探討臺中市65歲以上之老年人口骨質代謝狀況;此外我們並探討會影響老年人骨代謝速率的因素。研究對象包括396人,男性238人,女性158人,另包括年輕健康志願者70人為對照組,我們測量的骨分解指標為deoxypyridinoline(Dpd),生成指標為bone alkaline phosphatase(BAP)。結果顯示,老年女性不論在骨生成指標及骨分解指標皆比男性為高,且高於對照組。我們以高於同性別對照組 1SD以上者為過高標準,結果發現有17.6%男性及42.2%女性其Dpd過高;有18.3%男性及54.1%女性其BAP值過高,顯示老年男性與年輕男性的值相似,而老年女性的則較高。分析引起骨生化代謝指標過高的原因,發現性別差異對指標值影響最大,女性明顯高於男性;此外,最近一年曾經發生骨頭受傷或開刀者,其BAP及Dpd值會較高;而體重愈重者,其Dpd值較低。其他因素無統計上意義。因骨生化代謝指標過高代表有骨質流失增加的可能,且高骨代謝速率會造成骨頭微結構的改變,因此老年女性是骨質疏鬆症及發生骨折的高危險群。 |
英文摘要 | It has been noted that some bone biochemical markers are increased with rapid bone loss and which can be served as a predictor for a higher risk of osteoporotic fractures. After stratified random sampling, a total of 396 elderly people aged over 65 were recruited for this study. The purpose of the study is to evaluate the bone turnover rate in the elderly by assessing bone biochemical markers. We also wanted to find the causative factors in the elderly with a high bone turnover rate. There are many markers of bone metabolism which have been validated for assessing the bone turnover rate and in clinical use for years. In this study, one marker of bone resorption, urinary creatinine corrected free deoxypyridinoline (Dpd) and another one, serum bone alkaline phosphatase (BAP) were measured. The results showed that in the elderly females, bone Dpd and BAP values were significantly higher than those in the elderly males and the healthy controls. We found that there were 17.6% of males and 42.2% of females with the Dpd values, and 18.3% of males and 54.1% of females with BAP values 1SD above the means of control group. In multivariate regression models, both the markers were significantly higher in the elderly females than in the males. We also found that those who had sustained at least bone fracture or surgery on bones during the last year had an altered bone turnover with an increased level of bone resorption and formation markers. It was noted that the body weight was negatively associated with the Dpd values. Since bone lost is due to the imbalance between the bone resorption and formation, and a high bone turnover rate is associated with the bone microarchitecture changes during remodeling, therefore, the elderly have a higher risk of osteoporosis and subsequent fracture, especially so have females. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。