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題 名 | 甲基丙烯酸甲酯誘發倉鼠頰囊袋的病理變化=Pathologic Changes of Hamster Buccal Pouches Induced by Methyl Methacrylate |
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作 者 | 黃富美; 張育超; 江惠卿; 江濤; 周明勇; | 書刊名 | 中華牙醫學雜誌 |
卷 期 | 17:3 1998.09[民87.09] |
頁 次 | 頁165-171 |
分類號 | 410.025 |
關鍵詞 | 甲基丙烯酸甲酯; 動物模型; 致癌性; 腫瘤形成; Methyl methacrylate; Animal model; Tumorgenesis; Carcinogenesis; |
語 文 | 中文(Chinese) |
中文摘要 | 甲基丙烯酸甲酯(Methyl Methacrylate;簡稱MMA)被廣泛使用於製造日常 生活用品及醫療材料上,並且會殘存於自然界中,已被證實為一環境污染物。本 實驗利用倉鼠(Golden Syrian Hamster)頰囊袋粘膜塗抹的動物模型來探討MMAA原 液對倉鼠的致癌性。每週塗抹MMAA 5次,連續32週,結果發現塗抹MMA原液組 倉鼠頰黏膜結果如下:第一週可見上皮上多形性自血球(polymorphil neutrophils;PMNs)浸潤與形成微膿腫(microabscess)的發炎現象。第二週:發現有上皮 壞死,且發炎持續進行中。第三週與第四週:發炎現象消退許多,偶而可見微膿 腫及多形性自血球浸潤。第八週:偶而可見多形性白血球浸潤,但已不見微膿腫。 第十週:發炎現象幾乎完全消退,開始可見類似脂肪細胞的空泡狀組織浸潤在黏 膜下結締組織(submucosa)處。第十八週:表皮開始出現一個個微小乳頭狀突起、過 度角化與增生的上皮組織。而第二十六週與三十二週:有乳頭瘤(papilloma),纖維 瘤(fibroma)與類似結締組織的腫瘤(desmoid-liketumor)出現。在倉鼠動物塗抹實驗 中雖尚不能對MMA具有致癌性下定論,但MMA可能與腫瘤的形成有關。 |
英文摘要 | Methyl Methacrylate (MMA), a liquid monomer, is widely used to dental prosthesis.Syrian hamster cheek pouches were use in this study to elucidate the role of MMA onoral carcinogenesis. In the experimental group, 35 left hamster cheek pouches weregiven topical applications of MMA five times a week for 32 weeks. Three hamsterswere sacrificed at 1, 2, 3, 4 and 8 weeks and five hamsters were sacrificed at weeks10, 18, 26 and 32. Fifteen untreated hamsters cheek pouches were used as the control.The pouches were resected and fixed in 10 formalin; sections in paraffin were stainedwith hemaloxylin and eosin. Epithelial necrosis and microabscess formation were seenby the 2nd week, and fatty tissue infiltration in the subrnucosa by the 10th week. Epithelial hyperplasia, hyperkeratosis and parakeratosis were found at week 18. Moreover atthe end of the 32nd week, papilloma, submucous fibroma and desmoid-like tumors werefound. In conclusion, MMA might be more closely linked to tumorgenesis rather thancarcinogenesis. |
本系統中英文摘要資訊取自各篇刊載內容。