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題 名 | 氯氮平引發顆粒性白血球缺乏症後再試用經驗: 一例報告=Absence of Clozapine-Induced Agranulocytosis Following Long-Term Rechallenge: Report of One Case |
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作 者 | 陳國華; 林式穀; 張美智; 胡維恒; | 書刊名 | 臺灣精神醫學 |
卷 期 | 12:1 1998.03[民87.03] |
頁 次 | 頁79-83 |
分類號 | 418.21 |
關鍵詞 | 氯氮平; 顆粒性白血球缺乏症; Clozapine; Agranulocytosis; Rechallenge; |
語 文 | 中文(Chinese) |
中文摘要 | 目的:氯氮平對難治型精神分裂症的治療有較令人滿意的結果,但對白血球的抑制副 作用一直是個臨床上困擾的問題,因此對此現象的熟悉是非常重要的。病例報告:本文報告一 位男性精神分裂症個案,在使用氯氮平六週後出現顆粒性白血球缺乏症,後停用氯氮平,待 血中顆粒球數目回復正常,再度試用此藥劑達4年而未再出現此副作用之經驗,並對此作一文 獻回顧。結論:氯氮平的使用必須配合定期的抽血追蹤,早期確認顆粒性白血球數下降和停藥 是最重要的,吾人在使用此藥物時,必須時刻注意危險的顆粒性白血球缺乏症出現,至於再 使用經驗則]需未來更多的臨床資料。 |
英文摘要 | Objective: Clozapine is an antipsychotic prescribed for refractory schizophrenia and other special conditions of some psychotic disorders in recent years. The general use of clozapine is restricted due to the associated high incidence of agranulocytosis. Case Report: After six weeks of treatment with clozapine, a male schizophrenic patient treated with clozapine developed severe agranulocytosis. The patient's white blood cell count returned to its normal range after two weeks of discontinuing clozapine with first one week of using preventive antibiotic. No sequela was detected. The patient was again administered (rechallenged) clozapine, this time with close monitoring of his white blood cell count. His mental condition remained fairly stable under clozapine therapy, while no agranulocytosis was found again for more than four years. Related literature about the aversive effects of agranulocytosis, its mechanisms (mainly involving immunity) and management experience (supportive therapy and immunostimuating agent) is reviewed and discussed. Conclusion: Agranulocytosis is the most serious side effect of clozapine usage. Regular monitoring of the white cell count is necessary, as the early detection of agranulocytosis and discontinuation of clozapine can be life-saving. Understanding the indications for rechallenging requires additional case reports and clinical experience for complete evaluation. (Full Text in Chinese) |
本系統中英文摘要資訊取自各篇刊載內容。