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題名 | Giant Somatosensory Evoked Potentials in Rats with Urea-Induced Stimulus-Sensitive Myoclonus=巨大體性感覺誘發電位在尿素誘發刺激性敏感性肌陣攣之老鼠 |
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作者 | 謝慶良; 唐娜櫻; 謝慶竇; 林昭庚; | 書刊名 | 中國醫藥學院雜誌 |
卷期 | 7:4 1998.12[民87.12] |
頁次 | 頁17-23 |
分類號 | 415.149 |
關鍵詞 | 巨大體性感覺誘發電位; 尿素誘發刺激性敏感性肌陣攣; 行為; Giant somatosensory evoked potentials; Urea-induced stimulus-sensitive myoclonus; Ketamine; Behavior; |
語文 | 英文(English) |
中文摘要 | 我們研究尿素( 4.5g/Kg )誘發肌陣攣老鼠之病態生理。將 12 隻 Spragus-Dawley ( SD )大白鼠分成兩群: 1 )六隻用來做行為觀察並同時記錄它們的腦 波( EEG )和肌電圖( EMG );2 )六隻在 Ketamine 的麻醉狀態下記錄它們的體性感覺 誘發電位( SEPs ))。六隻大白鼠在腹腔注射尿素大約 20 分鐘後,它們的腦波從每秒中 6-8 Hz 的律動性活動轉變為每秒 2-3 Hz 的慢性活動, 然後所有大老鼠發展為刺激性敏感 性的肌陣攣。六隻大白鼠在 Ketamine 麻醉的狀態下,基線 SEPs 是由顯著的四個成份所構 成:P1 ( 7.5 ± 0.5 毫秒),N1 ( 8.2 ± 0.5 毫秒),P2 ( 10.6 ± 0.7 毫秒)和 N2 ( 16.6 ± 1.6 毫秒)。 N1-P2 和 P2-N2 兩個振幅呈現緩慢的增加在尿素注射後的二 小時達到最大,P1-N1 成份則維持不變。 根據這些結果我們猜想尿素能改變大腦皮質的興奮性,導致麻醉狀態下大白鼠體性感覺 誘發電位 N1-P2 和 P2-N2 成份的增大。這些很類似皮質性反射性肌陣攣病人的巨大體性感 覺誘發電位。由於 P1 成份已被認為是老鼠感覺皮質的起始反應,所以我們的結論是可以利 用這個巨大體性感覺誘發電位的動物模型來探討人類皮質性反射性肌陣攣的病態生理。 |
英文摘要 | We investigated the pathophysiology of urea (4.5 g/kg, i.p.)-induced myoclonus in rats. A total of 12 Sprague Dawley (SD) rats were divided into two groups: 1) Six rats were used for behavioral observation with EEG and EMG recordings: 2) somatosensory evoked potentials (SEPs) were recorded in 6 rats under anesthesia with ketamine. The baseline EEG showed 6-8 Hz rhythmic activities which were replaced by 2-3 Hz slow activities about 20 min after the administration of urea. Then, all the animals developed stimulus-sensitive myoclonus. In 6 rats with ketamine anesthesia, baseline SEPs consisted of 4 distinct components: P1 (7.5±0.5 msec), N1 (8.2±0.5 msec). P2 (10.6±0.7 msec) and N2 (16.6±1.6 msec). Both N1-P2 and P2-N2 components of SEPs showed a granual increase in amplitude and reached their maximum 2 hours after urea administration, while the P1-N1 component essentially remained unchanged. These results suggest that urea alters cortical excitability, which results in augmentation of the N1-P2 and P2-N2 components of SEPs in anesthetized rats. This is similar to the giant SEPs observed in humans with cortical reflex myoclonus. Because P1 has been considered to be an initial response of the somatosensory cortex in rats, we conclude that this animal model of giant SEPs may offer an insight into the pathophysiology of cortical reflex myoclonus in humans. |
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