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題名 | 以免疫組織化學法則測定膀胱移行上皮癌組織胚胎抗原(CEA)在臨床病理的相關性=Immunohistochemical Demonstration of Carcinoembryonic Antigen (CEA) and Its Clinicopathological Correlation with Transitional Cell Carcinoma of Urinary Bladder |
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作者 | 陳黎明; 簡崇和; 江金培; 黃俊雄; 周以和; 王起杰; | 書刊名 | 中華民國泌尿科醫學會雜誌 |
卷期 | 9:4 1998.12[民87.12] |
頁次 | 頁179-185 |
分類號 | 415.1461 |
關鍵詞 | 癌胚胎抗原; 膀胱癌; 預後; Carcinoembryonic antigen; Bladder tumor; |
語文 | 中文(Chinese) |
中文摘要 | 本研究以抗人 CEA 之免疫血清利用 Peroxidase-anti-Peroxidase 方法將 61 例 膀胱移行性上皮細胞癌作 CEA 免疫組織化學染色以測定癌組織中 CEA 之含量。我們發現腫 瘤期別愈高者及癌細胞分化愈差者 CEA 陽性比率愈高; 其中表淺性膀胱癌 (Superficial Bladder Cancer) 之癌細胞 CEA 呈現陽性比率為 30%; 而深層浸潤性膀胱癌 (deep invasive bladder cancer) 其癌細胞 CEA 呈現陽性比率為 54% (P<0.05); 而癌細胞分化 良好者 CEA 呈現陽性比率為 17%, 中等分化者為 35%, 而癌細胞分化者最差者為 50% (P<0.05)。 30 例表淺性膀胱癌患者中 9 例為 CEA 陽性,21 例 CEA 陰性,18 例在手術後發生再 發性腫瘤,其中 CEA 陽性佔 5 例(55%),CEA陰性佔13例(62%),此在統計學上不具顯 著意義差異(P>0.05);然而 5 例 CEA 陽性患者中有 2 例 (40%) 及 13 例 CEA 陰性患 者中有 2 例 (16%) 發生浸潤性再發腫瘤, 顯示 CEA 陽性患者術後較易產生浸潤再發性腫 瘤 (P<0.05)。 24 例 CEA 陽性患者中有 5 例 (20%) 活超過 5 年,相反的,37 例 CEA 陰性患者中有 26 例 (70%) 活超過 5 年, 顯示癌細胞組織 CEA 呈現陽性反應者預後 較差 (P<0.05)。 |
英文摘要 | Immunoperoxidase method was used to study the tumor expression of carcinoembryonic antigens (CEA) in 61 patients with transitional cell carcinoma of the urinary bladder. In our study, the presence of CEA in cancer tissues correlates well with the tumor stage. CEA was positive in 30% of superficial tumor tissue, and 48% of invasive cases (P<0.05). There is a significant correlation between CEA expression and differentiation of the tumor; in well-differentiated tumors, CEA was found in the tumor tissue in 17% of cases, however, 42% of poorly differentiated carcinomas were CEA-positive. (P<0.05). Among the 30 patients in this study (9 were CEA positive and 21 had CEA negative) with superficial tumors, 18 of them developed recurrent tumors after surgery, and among these 5 (55%) were CEA postitive and 13 (62%) were CEA negative (P<0.05). Two (40%) of 5 CEA-postitive cases and 2 (16%) pf 16 CEA-negative cases subsequently developed invasive tumors, indicating that patients with CEA positive were more liable to develop invasive tumors (P<0.05). A significant correlation (P<0.05) was also observed between the presence of CEA and the prognosis. In this study, 5 (20%) of the 24 patients with CEA-positive tumors lived for more than 5 yr; in contrast, 26 (70%) of the 37 CEA-negative patients live for more than 5 yr. |
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