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題 名 | Recent Advances in Gene Therapy of GI and Liver Diseases=胃腸及肝臟疾病基因治療之新進展 |
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作 者 | Wu,George Y.; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 39:5 民87.09-10 |
頁 次 | 頁297-300 |
分類號 | 415.5 |
關鍵詞 | 基因治療; 胃; 腸; 肝臟; Genes therapy; Viral vector; Liposome; Receptormediated gene delivery; |
語 文 | 英文(English) |
英文摘要 | Gene therapy toward the digestive organs has made substantial progress. The strategies applied include ex vivo and in vivo delivery. The ex vivo pathway does not require a tissue-specific vector while the in vivo pathway .is advantageous for tissues not obtainable or hard to culture. The specific vectors of gene delivery for the liver and gastrointestinal tract include (1) viral vectors: retrovirus, adenovirus, and adeno-associated virus are the three most common currently used. (2) liposomes: when cationic substances are incorporated, DNA can be coated on the surface and carried into cells. (3) receptormediated gene therapy: natural and physiological and tissue-specific ligands were incorporated and modified to carry foreign DNA into the cells. They are tissue-specific and relatively nontoxic. The innovations focus on the prolongation of gene expression and a more efficient gene delivery. |
本系統中英文摘要資訊取自各篇刊載內容。