頁籤選單縮合
題名 | Synthesis and Antiplatelet Activity of 1,3-Disubstituted 5-Methylthieno[3,2-c]Pyrazoles=1,3-雙取代-5-甲基噻吩駢[3,2-c]吡唑類衍生物之合成及其抗血小板凝集活性 |
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作者 | 蔡勝忠; 鄧哲明; 郭盛助; Tsai, Sheng-chung; Teng, Che-ming; Kuo, Sheng-chu; |
期刊 | 中國醫藥學院雜誌 |
出版日期 | 19980900 |
卷期 | 7:3 1998.09[民87.09] |
頁次 | 頁165-172 |
分類號 | 418.1 |
語文 | eng |
關鍵詞 | 噻吩駢[3,2-c]吡唑; 1,3-雙取代-5-甲基噻吩駢[3,2-c]吡唑; 抗血小板凝集性; Thieno[3,2-c]pyrazole; 1,3-disubstituted 5-methylthieno[3,2-c]pyrazole; Antiplatelet activity; |
中文摘要 | 合成一系列1,3-雙取代-5-甲基�悝h駢﹝3,2-c﹞�p唑類衍生物(6a-h),並測試其抗血小板凝集活性,結果發現有些化合物具有相當意義的活性,其中以1,3-雙酚基-5-甲基�悝h駢﹝3,2-c﹞�p唑(6a)之活性最具潛力,可提供將來開發抗血小板凝集劑的基本結構。 |
英文摘要 | A series of 1,3-disubstituted 5-methylthieno ﹝3,2-c﹞pyrazoles (6a-h) were synthesize and examined for their antiplatelet activities. Some of these compounds showed significant activity. Among them, 1,3-diphenyl 5-methylthieno ﹝3,2-c﹞pyrazole (6a) was found to be the most promising agent which could provide a novel structural prototype for antiplatelet agents. |
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