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題名 | 當歸補血湯對缺血性大鼠被動迴避學習反應障礙之影響=Effect of TANG-KUEI-PU-HSUEH-TANGS on the Impairment of Passive Avoidance Ler-Aning in Rats Exposed to Cerebral Ischemia |
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作者 | 林穎志; 謝明村; 吳龍源; 彭文煌; | 書刊名 | 中國醫藥學院雜誌 |
卷期 | 7:3 1998.09[民87.09] |
頁次 | 頁157-163 |
分類號 | 414.5 |
關鍵詞 | 當歸補血湯; 腦缺血大鼠; 被動迴避; Tang-kuei-pu-hsueh-tangs; PHT; Cerebral ischemia rats; Passive avoidance; |
語文 | 中文(Chinese) |
中文摘要 | 本研究以被動迴避學習儀探討當歸補血湯水抽取物及95%乙醇抽取物對雙側頸動脈缺血大鼠被動迴避學習反應之影響,結果顯示雙側頸動脈缺血大鼠於缺血第二天及第十天會產生被動迴避學習反應障礙,當給予當歸補血湯水抽取物及95%乙醇抽取物每天一次,連續給二天或十天對雙側頸動脈缺血大鼠產生之被動迴避學習反應障礙有顯著改善作用。電痛刺激實驗顯示,當給予當歸補血湯水抽取物及95%乙醇抽取物每天一次,連續給二天或十天對雙側頸動脈缺血大鼠之痛閾值並無影響。運動量實驗結果顯示,當給予當歸補血湯水抽取物及95%乙醇抽取物每天一次,連續給二天或十天對雙側頸動脈缺血大鼠之運動量降低有明顯增加作用。 綜合以上結果顯示,當給予當歸補血湯水抽取物及95%乙醇抽取物每天一次,連續給二天或十天對雙側頸動脈缺血大鼠之被動迴避學習反應障礙有顯著改善作用。 |
英文摘要 | In this study, we used the passive avoidance task to investigate the effects of the water or ethanol extracts of Tang-Kuei-Pu-Hsueh-Tangs (PHT) on the impairment of passive avoidance learning in rats exposed to cerebral ischemia. The rats after the occulusion of carotid vessels for two or ten days produced the impairment of passive avoidance learning. The water or ethanol extracts of PHT at 0.5, 1.0g/kg dose administered for two days or ten days improved the the impairment of passive avoidance learning produced by cerebral ischemia rats. This improssive effects of PHT were not affected by the the changes of the pain threshold. The water or ethanol extracts of PHT also improved the hypomotilities produced by cerebral ischemia rats. In conclusion, the water or ethanol extracts of PHT improved the impairment of passive avoidance learning produced by cerebral ischemia rats. |
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