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題名 | 黃耆對腦缺血大鼠被動迴避學習反應障礙之影響=Effects of Astragalus Radix on the Impairment of Passive Avoidance Leraning in Rats Exposed to Cerebral Ischemia |
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作者 | 彭文煌; 謝明村; 林穎志; | 書刊名 | 中國醫藥科學雜誌 |
卷期 | 1:1 2000.03[民89.03] |
頁次 | 頁17-23 |
分類號 | 414.5 |
關鍵詞 | 黃耆; 黃耆多醣; 腦缺血大鼠; 被動迴避; 腦血流量; Astragalus radix; Astragalus polysaccharides; Cerebral ischemia rats; Passive avoidance; |
語文 | 中文(Chinese) |
中文摘要 | 本研究探討雙側頸動脈結紮大鼠口服投與黃耆水抽取物及腹腔注射黃 耆活性成分黃耆多醣,對被動迴避學習反應之影響,並以電痛刺激實驗及大鼠自 發運動量儀測定缺血大鼠之痛閾值及運動量改變,結果顯示雙側頸動脈結紮大鼠 於結紮第二天及第十天會產生被動迴避學習反應障礙與腦血流減慢,當給予黃耆 水抽取物及黃耆多醣每天一次,連續給與二天或十天對雙側頸動脈結紮大鼠產生 之被動迴避學習反應障礙有顯著改善作用,對雙側頸動脈缺血大鼠之痛閾值並無 影響。對雙側頸動脈結紮大鼠之運動量降低有明顯增加作用。黃耆多醣連續腹腔 給與二天或十天對雙側頸動脈結紮大鼠之腦血流減慢也具顯著改善作用。綜合以 上結果顯示,當給予黃耆水抽取物與黃耆多醣每天一次,連續給二天或十天對雙 側頸動脈缺血大鼠之被動迴避學習反應障礙有顯著改善作用。此改善作用可能與 黃耆多醣增加缺血大鼠腦血流量,改善大鼠缺血有關。 |
英文摘要 | In this study, we used the passive avoidance task to investigate the effects of the water extract of Astragalus Radix (Astw) and Astragalus polysaccharide (APS) on the impairment of passive avoidance learning in rats exposed to cerebral ischemia. The rats after the occulusion of carotid vessels for two days or ten days produced the impairment of passive avoidance learning. The Astw at 0.5、1.0 g/kg and APS at 0.1、0.5g/kg administered for two or ten days improved the impairment of passive avoidance learning produced by cerebral ischemia rats. This improssive effects of Astw and APS were not affected by the changes of the pain threshold. The Astw and APS also improved the hypomotilities produced by cerebral ischemia rats. Furthermore, APS increased the brain blood flow in the cerebral ischemia rats . In conclusion, the Astw and APS improved the impairment of passive avoidance learning produced by cerebral ischemia rats. The improssive effect of Aps may be related to the inrease in the cerebral blood flow. |
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