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題 名 | 厚朴不同炮炙品之藥理學比較研究=Comparative Pharmacological Studies on the Decoctions of Magnolia Officinalis |
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作 者 | 謝明村; 黃秀華; 彭文煌; 林穎志; 張光雄; | 書刊名 | 中國醫藥學院雜誌 |
卷 期 | 7:3 1998.09[民87.09] |
頁 次 | 頁69-79 |
分類號 | 414.5 |
關鍵詞 | 厚朴; 炮炙; 藥理學; Magnoliae cortex; Preparations; Pharmacology; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究將厚朴各炮炙品(生品、薑浸、薑煮、薑炒焦),分別以水及95 %乙醇抽取,再以鎮靜、肌肉鬆弛、抗痙攣、抗浮腫等實驗探討各炮炙品藥理作用之差異性,並進一步探討藥理作用最有效炮炙品的作用轉機。最後以高效液相層析法(HPLC)測定厚朴各炮炙品中所含厚朴酚(magnolol)及和厚朴酚(honokiol)之含量,以探討其藥理作用與成分間關係。 實驗結果顯示,厚朴各炮炙品95%乙醇粗抽取物具有延長hexobarbital誘發的睡眠時間,抑制大鼠運動量,延長strychnine所引起之clonic convulsion 的時間及picrotoxin所引起tonic convulsion 的時間,對由λ-carrageenan誘發發炎有抑制作用,且不具肌肉鬆弛作用。其中以生品95%乙醇粗抽取物之藥理作用最強,且能增強由α-MT、5-HTP、muscimol所誘發之運動量降低作用,減弱apomorphine、PCPA所誘發之運動量興奮作用。又由高效液相層分析法(HPLC)中測得厚朴各炮炙品95%乙醇粗抽取物中厚朴酚及和厚朴酚含量,其中以生品含量最高,其次為薑浸、薑煮、薑炒焦,而水抽取物則具肌肉鬆弛作用,但並未測得厚朴酚及和厚朴酚之含量。 綜合上述,厚朴各炮炙品95%乙醇粗抽取物具鎮靜,抗痙攣,抗浮腫等作用,其中以上品95%乙醇粗抽取物之藥理作用最顯著,而其鎮靜轉機則可能與抑制catecholaminergic system 活性及增加serotonergic system和GABAergic system之活性有關。 |
英文摘要 | In this study, four different decocted from of magnolia officinalis-raw, dipped, boiled and scorched were extracted with water and 95% ethanol separately. We compared the analgesic, muscle relaxation, anticonvulsive and antiinflammatory effects of each decocted Houpo. The contents of magnolol and honokiol were also measured by HPLC method. The results showed that the 95% ethanol crude extracts prolonged the sleeping time induced by hexobarbital in mice, clonic convulsion time induced by strychnine and tonic convulsion time induced by picrotoxin, and redued the locomotor activity in rats the swelling volume, of rat's. hind-paw induced by carrageenan. It potentiated the hypomotility produced by(MT, 5-HTP, muscimol. It also reduced the hypermotility produced by apomorphine, PCPA. Among the ethanol crude extract of magnolia officinalis, the raw magnolia officinalis has the highest contents of magnolol and honokiol, and the dipped magnolia officinals is ranks second high, while boiled Hopu ranks next and the scorchedmagnolia officinalis comes last. The water crude extracts had the function of muscle relaxation but can not find the contents of mognolol and honokiol. From these results, it was found that the 95% ethanol crude extracts had analgesic, anticonvulsive and antiinflammatory effects. The hypomotility produced by the 95% ethanol crude extract of raw magnolia officinalis might be involved in the inhibition of the catecholaminergic system activities and the increase of the serotonergic and GABAergic activities. |
本系統中英文摘要資訊取自各篇刊載內容。