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題 名 | 人工合成腐植酸對血液凝固因子蛋白質C的影響=The Inhibition of Plasma Protein C Activity Induced by Synthetic Humic Acid |
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作 者 | 楊新玲; 周湘臺; 呂鋒洲; | 書刊名 | 中臺灣醫學科學雜誌 |
卷 期 | 3:3 1998.09[民87.09] |
頁 次 | 頁160-165 |
分類號 | 415.62 |
關鍵詞 | 人工合成腐植酸; 多酚酸聚合物; 蛋白質C; 三價砷; Synthetic humic acid; Polyphenolic polymers; Protein C; As[feaf]O[feb0]; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究目的是探討人工合成腐植酸(synthetic humic acid polymer, SHA)及砷(As�烙�陛^對血液凝固因子蛋白質C(Protein C)活性的影響。我們發現四種單一酚酸(protocatechuic acid、venillic acid、catechol、ferulic acid)合成之多酚酸聚合物即人工合成腐植酸,可抑制活化型蛋白質C的活性和減少未活化型蛋白質C的活性速率,但三價砷則會促進。人工合成的腐植酸螯合三價砷具協同作用,會更強烈抑制蛋白質C的活性,走向促進血液凝固。 |
英文摘要 | In this study we examined the effect of synthetic humic acid (SHA) and arsenic oxide (AS�烙��) on human protein C activity. We found that four SHAs polymerized from monomeric protocatechuit acid, venillic acid, catechol and ferulic acid have the ability to dose-dependently inhibit both activated protein C activity and the activation of protein C. Arsenic oxide dose-dependently enhanced activated protein C activity. However, SHA-arsenic organometallic complex is more effective in the inhibition of activated protein C activity. Protein C induced by SHA causes a thrombophilic or hypercoagulablestate, which may be one of the possible mechanisms of blackfoot disease. |
本系統中英文摘要資訊取自各篇刊載內容。