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題 名 | β-Lactam Resistance and β-Lactamase Isoforms of Moraxella Catarrhalis Isolates in Taiwan=臺灣地區Moraxellacatarrhalis菌株之貝他內醯胺類藥物抗藥性及貝他內醯胺酶之分型 |
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作 者 | 馮長風; 李細祥; 廖旭方; 王復德; 郭英調; 劉正義; 劉有增; 劉永慶; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 97:7 1998.07[民87.07] |
頁 次 | 頁453-457 |
分類號 | 418.284 |
關鍵詞 | Moraxellacatarrhalis菌株; 貝他內醯胺類藥物; 抗藥性; 貝他內醯胺酶; Moraxella catarrhalis; β-lactamase; Antibiotic resistance; |
語 文 | 英文(English) |
英文摘要 | Moraxella catarrhalis is an important pathogen in both upper and lower respiratory tract infections. More than 90% of isolates worldwide produce β -lactamase. The β -lactamases produced by M. catarrhalis can be differentiated by isoelectric focusing (IEF) into BRO-1 and BRO-2 patterns. In this study, we investigated the prevalence of various β -lactamase isoforms in clinical isolates of M. catarrhalis in Taiwan, as well as the relationships of these isoforms with antibiotic resistance. A total of 271 clinical isolates of M. catarrhalis were collected from 12 large medical laboratories in Taiwan from 1 August 1993 to 31 July 1995. The overall prevalence of β -lactamase production was 98.2% (266 of 271 isolates). Analytical IEF revealed BRO-1 was the most common β -lactamase pattern among the isolates (238 isolates, 88%); BRO-2 was the only other pattern found, with 32 (12%) isolates. The geometric mean minimum inhibitory concentration of ampicillin for BRO-1 producers was 63-fold higher than that for β -lactamase-negative isolates, and 6.5-fold higher than that for BRO-2 producers, β -Lactam antibiotics, such as amoxicillin + clavulanate and the cephalosporins, tested were very active against this species, regardless of whether the isolate produced β -lactamase or not. In conclusion, β -lactamase is common among clinical isolates of M. catarrhalis in Taiwan, with BRO-1 being the most common isoform. However, because most isolates tested were still sensitive to amoxicillin + clavulanate and cephalosporins, these agents appear to be reliable alternatives to first-line therapy when M. catarrhalis is contributing to a clinical infection. |
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