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題 名 | 以O/W乳化添加非溶劑法製備水溶性藥物微膠囊=Preparation of Microcapsules Containing Water-Soluable Drug by using O/W Emulsion Non-Solvent Addition Method |
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作 者 | 蔡燕鈴; 彭瑞坤; 陳暉; | 書刊名 | 界面科學會誌 |
卷 期 | 21:1 1998.04[民87.04] |
頁 次 | 頁17-30 |
分類號 | 418.632 |
關鍵詞 | 微膠囊; 乙基纖維素; O/W乳化; 非溶劑添加法; Microcapsules; Ethylcellulose; O/W emulsion; Non-solvent addition method; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究以O/W乳化添加非溶劑法製備水溶性藥物(茶葉鹼TH)微膠囊之製備,選用乙基纖維素(EC)為殼物質,二氯甲烷為溶劑,正己烷為非溶劑。因此O/W乳化法製備水溶性藥物微膠囊會導致藥物損失過大,所以本實驗除了探討包覆過程之藥物損失外,並謀求改善藥物損失的方法,同時對微膠囊之粒徑大小、表面形態、藥物溶出速率及動力學特性亦加以討論。實驗結果得知,藥物損失之95%發生在包覆溶液(高分子溶液)分散在水相溶液(分散介質)中的前5分鐘。為減少藥物損失,我們選用下列4種方式來製備微膠囊:(1) 改變高分子溶液濃度,(2) 於包覆溶液中添加非溶劑,(3) 選用甲苯作為二氯甲烷之混合溶劑,(4) 於分散介質中預先添加非溶劑。結果發現,由此4種方式所製備之微膠囊其藥物損失量皆有減少,且除了包覆溶液中添加非溶劑之方式外,其餘三種方式皆可將藥物損失率降低20%左右,對減低藥物損失之效果良好。在溶出試驗方面,可知藥物之溶出速率受微膠囊表面形態影響甚大,且本研究所製備出之微膠囊,其藥物溶出20%所需時間 (T��) 從1.8小時至82.3小時,藥物制放之時間範圍甚廣。而不論以何種方式製備出之微膠囊,其溶出動力學皆符合一階及Higuchi溶出模式。 |
英文摘要 | The microcapsules containing water-soluale drug (theophylline, TH) were prepared by O/W emulsion non-solvent addition method. Ethylcellulose was chosen as the wall material, and dichloromethanebn-hexane was chosen as the solvent-nonsolvent pair. When the microcapsules containing water-soluable drug were prepared by using O/W emulsion method, the drug of microcapsules has a strong tendency to dissolve in the intermediate. Therefore, the work to reduce the drug loss during the preparation of microcapsules was undertaken. The drug loss of 95% of microcapsules took place in the first five minutes for encapsulation solution dispersed in intermediate. Thus, four methods of preparation of microcapsules were proposed to reduce drug loss, e.g., microcapsules prepared by: (1) changing the concentration of polymer solution, (2) adding the non-solvent in polymer solution, (3) choosing toluene as the mixed solvent of dichloromethane, (4) adding the nono-solvent in intermediate. The drug loss of microcapsules that prepared by the methods of (1)-(4) was obviously reduced. Moreover, the methods of (1),(3) and (4) could reduce the drug loss of microcapsules about 20%. On the other hand, the release rate of microcapsules is strongly affected by the surface morphology of microcapsules. The surface morphology of microcapsules prepared by the four method have obvious discrepancy. This result induced the range of these release rates were broad. Dissolution studies showed that the release rate of these microcapsules fitted first order and Higuchi spherical matrix models. |
本系統中英文摘要資訊取自各篇刊載內容。