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題名 | 硼中子捕獲治療的輻射劑量與品質之研究=Radiation Dose and Quality of Boron Neutron Capture Therapy |
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作者 | 許芳裕; 董傳中; Hsu, Fang-yuh; Tung, Chuan-jong; |
期刊 | 放射治療與腫瘤學 |
出版日期 | 19980600 |
卷期 | 5:2 1998.06[民87.06] |
頁次 | 頁127-133 |
分類號 | 418.94 |
語文 | chi |
關鍵詞 | 中子治療; 硼中子捕獲; 有效射質因數; Neutron therapy; Boron neutron capture therapy; Effective quality factor; |
中文摘要 | 目的:近年來,癌病已成為人類死亡的主要病因,因此科學家正頃全力研究癌病 的起因、防治、與診療。目前清華大學正利用清華水池式反應器,進行硼中子捕獲治療法(Boron Neutron Capture Therapy,簡稱BNCT)之中子屏蔽、藥物研發、生物實驗、劑量評估等研 究。本文之目的,即在於評估硼中子捕獲治療的輻射劑量與品質。 材料與方法:硼中子捕獲治療法是利用藥物將硼-10同位素帶入人體,使之累積在腫瘤 組織中,再以熱(或超熱)中子束照射,使中子和硼發生核反應,釋出高游離密度與短射程的 粒子輻射,有效殺死腫瘤組織而不影響正常組織。其所造成吸收劑量的主要貢獻有α粒子劑 量及鋰-7重核粒子劑量。若代入等效劑量的定義,可求得腫瘤組織的有效射質因數Q;若代 入等值劑量的定義,即可求得正常組織及腫瘤組織的有效輻射加權因數W□。 結果:當體內腫瘤組織含硼濃度增加時,在低濃度等效劑量與含硼濃度呈非線性比例的 關係,在高濃度時則呈線性正比的關係,當腫瘤組織含硼濃度太低時,有效射質因數會降低, 使得腫瘤組織與正常組織的輻射致死效應相當,而減低BNCT的治療效益。 結論:本研究已開發完成等效劑量(dose equivalent)、有效射質因數(effective quality factor)、等值劑量(equivalent dose)、有效輻射加權因數(effective radiation weighting factor)的評估程式,由外部輸入或利用系統內建的中子能譜、中子通量率、及腫瘤組織之 含硼濃度等條件,進行各種核反應引起的輻射劑量與輻射品質的探討。 |
英文摘要 | Purpose: A beam port of epithermal neutrons at Tsing Hua Open Pool Reactor (THOR) was recently built. This port was designed for basic research on boron neutron capture therapy (BNCT). The research team consisted of radiobiologists, pharmaceutical chemists, medical scientists, nuclear engineers, and health physicists. The dosimetry group took the responsibility for the assessment of tumor/normal tissue biological doses. Radiation dose and quality were assessed in this work. Materials and Methods: The basic principle of BNCT is to deliver □B-labeled drug to the patient. Isotope will accumulate in tumor mostly. Following the irradiation of an epithermal (thermal) neutron beam. □B(n,α)□Li nuclear reactions occur and short-range and high LET particles emit. These particles kill the tumor cells but unharm the normal tissues. We focus our study on equivalent doses, effective quality factors (Q) and effective radiation weighting factors (W□) by the dosimetric model. Result In low boron concentration, the relation between equivalent dose and boron concentration was nonlinear. At such concentration, when decreased, the radiation effects for tumor and normal tissues were approximately the same. The therapeutic effectiveness by BNCT was decreased. As boron concentration increased the relation became linear and the therapeutic effectiveness was better. Conclusion: A computer code was developed to calculate the dosimetric quantities from input of boron concentration, neutron flux and energy, irradiation geometry and time. Results were analyzed as a function of separate and combined input factors. Optimal irradiation conditions were recommended for future clinical application. |
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