頁籤選單縮合
題 名 | Optimized Neutron Beam for Boron Neutron Capture Therapy=用於硼中子捕獲療法之最適化中子束 |
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作 者 | El-khosht,M. A.; | 書刊名 | 核子科學 |
卷 期 | 34:4 1997.08[民86.08] |
頁 次 | 頁291-309 |
分類號 | 418.94 |
關鍵詞 | 硼中子捕獲療法; 最適化中子束; Boron neutron capture therapy; Optimized neutron beam; Review article; |
語 文 | 英文(English) |
英文摘要 | Incorporation of □B in human tumor treated with fast neutrons would increase the local energy dose in the tumor. The thermal neutrons can cause neutron capture reaction □B (n,α)□ Li in tissue. A sufficiently high number of thermalized neutrons is necessary combined with a possibly selective concentration of □B in the tumor as target volume for the clinical application. Neutron beams used for Boron Neutron Capture Therapy ( BNCT) are always accompanied by photons. Each radiation component of neutron and gamma has different Relative Biological Effectiveness (RBE) . Therefore it is necessary to determine the absorbed dose of these component in the mixed field separately. The epithermal neutrons beam should be gained and both the fast neutron and gamma doses per epithermal neutron should be reduced. Radiation transport programs have been specialized to achieve the □B-kenna contribution to 6% of the total skin kerma for the converted neutron beam with 8 cm x 8 cm field size. Hereby, 100,μg □B/g tissue are delivered in a tumor region localized between 1 cm and 5 cm depth. This value of kerma holds without any beam filter. Further studies are performed to improve the achieved value using appropriate filter materials. Also, current studies in Japan and recent studies in both Europe and USA concerning the treatment of tumor cells (brain and skin cancer) by BNCT are physical slightly reviewed. Recently, TRIGA-fueled slab core (at the Brookhaven Medical Research Reactor of BNL in New York) was designed to produce an epithermal and thermal neutron beams with low contamination suited to BNCT. Maximum operating power of 300 KW would provide a shorter treatment time and would be more comfortable for patients. |
本系統中英文摘要資訊取自各篇刊載內容。