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題 名 | Effectiveness of Ondansetron on Treatment of Cholestatic Pruritus in Patients with Advanced Hepatocellular Carcinoma |
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作 者 | Hung,Hung-chang; Huang,Hui-chun; Huang,Yi-shin; Chao,Yee; Teng,Ho-chung; Chang,Full-young; Lee,Shou-dong; | 書刊名 | 內科學誌 |
卷 期 | 9:2 1998.06[民87.06] |
頁 次 | 頁70-75 |
分類號 | 415.456 |
關鍵詞 | 膽汁鬱積; 搔癢; 嘔吐; 肝細胞症; Cholestasis; Pruritus; Ondansetron; |
語 文 | 英文(English) |
英文摘要 | The objective of the present study was to determine the effect of ondansetron, a specific serotonin type 3 (5-HT□) receptor antagonist, to relieve choletatic pruritus in patients resistant to conventional antipruritic therapy. In a placebo-controlled study the acute effect of an intravenous injection of ondansetron or placebo (normal saline) was tested in 12 cancer patients (mean age 61 ± 8.8 yr) with cholestatic itch. Each patient received ondansetron (8 mg and 4 mg) and placebo infusion consequently. The intensity of pruritus was assessed by a visual rating scale from 0 to 10 (most severe pruritus). A successful treatment was regarded when the intensity was reduced by 50% or more within 2 hours after injection of ondansetron. During the following 24 hours, the patients were assessed and the time point recorded when the intensity of pruritus relapsed into the same degree as pre-treatment. Intravenous application of ondansetron abolished pruritus within 60 min by a 50% reduction of the intensity of itching. The effect of ondansetron on itching intensity showed significant difference (p<0.001) from placebo during a controled observation period from 30 to 120 minutes. The onset of a successful treatment (18.3 ± 6.2 vs 36.8 ± 21.4 min, p<0.05) and the duration (8.3 ± 1.3 vs 4.0 ± 1.0 hours, p<0.01) were signficantly earlier and longer at a high dose. No side effects occurred during treatment. Our findings suggest that the 5-HT receptor antagonist may be a novel therapeutic alternative for the treatment of cholestatic pruritus. pruritus. |
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